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Table 3 Poisson segmented regression models of the impact of treat-all on mean CD4 at ART initiation among PLHIV in China 1 January 2015 to 31 December 2019

From: Immediate and long-term outcomes after treat-all among people living with HIV in China: an interrupted time series analysis

 

IRR (95% CI)

Level change at treat-all

P value

Level change in

December 2019

P value

Trend before treat-all

P value

Trend after treat-all

P value

Mean CD4

0.990 (0.956–1.026)

0.585

0.973 (0.842–1.124)

0.709

0.998 (0.995–1.001)

0.196

0.997 (0.997–0.998)

 < 0.001

Gender

        

 Male

1.001 (0.968–1.036)

0.941

0.955 (0.822–1.109)

0.548

0.998 (0.995–1.001)

0.213

0.997 (0.996–0.998)

 < 0.001

 Female

0.932 (0.891–0.976)

0.003

1.124 (1.092–1.156)

 < 0.001

0.996 (0.995–0.996)

 < 0.001

1.000 (0.999–1.001)

0.567

Age, years

        

 0–25

1.015 (0.976–1.056)

0.447

0.932 (0.748–1.160)

0.526

1.001 (0.997–1.006)

0.553

0.999 (0.999–1.000)

0.081

 26–35

1.002 (0.967–1.038)

0.926

0.881 (0.751–1.033)

0.118

1.001 (0.998–1.004)

0.553

0.998 (0.997–0.999)

 < 0.001

 36–50

1.007 (0.944–1.074)

0.841

1.134 (0.915–1.404)

0.250

0.995 (0.991–0.999)

0.022

0.998 (0.997–1.000)

0.060

 > 50

0.971 (0.876–1.076)

0.572

1.340 (0.921–1.949)

0.126

0.992 (0.985–0.998)

0.014

0.999 (0.998–1.000)

0.137

Route of transmission

        

 Heterosexual

0.936 (0.852–1.027)

0.163

1.137 (0.866–1.493)

0.357

0.995 (0.989–1.000)

0.058

0.999 (0.998–1.000)

0.170

 Homosexual

1.038 (0.994–1.084)

0.093

0.941 (0.837–1.057)

0.304

1.000 (0.997–1.002)

0.743

0.997 (0.996–0.998)

 < 0.001

 Others

1.024 (0.971–1.080)

0.380

0.908 (0.704–1.171)

0.458

1.001 (0.996–1.006)

0.727

0.998 (0.997–0.999)

0.001

Region

        

 Northern China

1.033 (1.001–1.065)

0.041

0.916 (0.808–1.040)

0.175

1.002 (1.000–1.004)

0.042

0.999 (0.998–1.000)

0.113

 Northeastern China

1.080 (1.003–1.164)

0.042

0.805 (0.689–0.941)

0.007

1.002 (0.999–1.005)

0.126

0.995 (0.993–0.997)

 < 0.001

 Southern China

1.004 (0.939–1.074)

0.900

0.700 (0.475–1.031)

0.071

1.006 (0.998–1.014)

0.118

0.998 (0.996–0.999)

0.001

 Southwestern China

0.926 (0.867–0.989)

0.022

1.145 (0.875–1.499)

0.322

0.993 (0.988–0.998)

0.010

0.998 (0.997–0.999)

0.003

 Eastern China

1.109 (0.971–1.268)

0.128

2.396 (1.589–3.614)

 < 0.001

0.982 (0.975–0.990)

 < 0.001

1.000 (0.998–1.003)

0.768

  1. IRR Incidence rate ratio, CI Confidence interval, ART Antiretroviral therapy. Treat-all: June 2016. PLHIV: People living with HIV. Region was divided into Northern China (Hohhot, Shijiazhuang, Beijing and Tianjin), Northeastern China (Dalian and Shenyang), Southern China (Guangzhou and Shenzhen), Southwestern China (Chongqing and Dehong), and Eastern China (Nanjing)