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Table 4 Poisson segmented regression models of the impact of treat-all on mean estimated time from infection to diagnosis among PLHIV in China 1 January 2015 to 31 December 2019

From: Immediate and long-term outcomes after treat-all among people living with HIV in China: an interrupted time series analysis

 

IRR (95% CI)

Level change at treat-all

P value

Level change in

December 2019

P value

Trend before treat-all

P value

Trend after treat-all

P value

Mean estimated time

to diagnosis

1.070 (1.021–1.120)

0.004

0.978 (0.811–1.178)

0.801

1.004 (1.000–1.007)

0.044

1.001 (1.000–1.003)

0.330

Gender

        

 Male

1.056 (1.010–1.104)

0.016

1.010 (0.846–1.206)

0.902

1.003 (1.000–1.007)

0.045

1.002 (1.001–1.003)

 < 0.001

 Female

1.148 (1.062–1.240)

 < 0.001

0.847 (0.714–1.005)

0.065

1.005 (1.002–1.009)

0.001

0.998 (0.997–1.000)

0.094

Age, years

        

  0–25

1.044 (0.979–1.113)

0.185

1.121 (0.828–1.518)

0.452

0.999 (0.993–1.005)

0.730

1.001 (1.000–1.002)

0.049

  26–35

1.053 (1.001–1.109)

0.048

1.137 (0.928–1.394)

0.208

1.000 (0.996–1.004)

0.968

1.002 (1.001–1.003)

0.011

  36–50

1.057 (0.987–1.132)

0.116

0.858 (0.682–1.078)

0.182

1.006 (1.002–1.011)

0.003

1.001 (1.000–1.003)

0.214

   > 50

1.078 (1.000–1.161)

0.046

0.737 (0.551–0.986)

0.045

1.009 (1.003–1.014)

0.001

1.000 (0.998–1.001)

0.604

Route of transmission

        

  Heterosexual

1.124 (1.042–1.213)

0.002

0.831 (0.584–1.181)

0.306

1.007 (1.000–1.013)

0.048

0.999 (0.998–1.001)

0.413

  Homosexual

0.996 (0.940–1.055)

0.907

1.100 (0.967–1.251)

0.139

1.001 (0.998–1.003)

0.520

1.003 (1.002–1.005)

 < 0.001

  Others

1.014 (0.952–1.079)

0.705

1.054 (0.767–1.449)

0.775

1.000 (0.994–1.007)

0.875

1.001 (1.000–1.003)

0.331

Region

        

 Northern China

0.994 (0.961–1.029)

0.776

1.141 (0.996–1.306)

0.055

0.997 (0.995–1.000)

0.064

1.001 (0.999–1.002)

0.235

 Northeastern China

0.962 (0.873–1.059)

0.440

1.484 (1.266–1.740)

 < 0.001

0.995 (0.992–0.999)

0.013

1.006 (1.003–1.008)

 < 0.001

 Southern China

1.015 (0.938–1.098)

0.760

1.399 (0.917–2.133)

0.125

0.994 (0.986–1.003)

0.205

1.002 (1.001–1.003)

0.003

 Southwestern China

1.129 (1.055–1.208)

 < 0.001

0.772 (0.591–1.008)

0.057

1.009 (1.004–1.014)

0.001

1.000 (0.998–1.001)

0.781

 Eastern China

0.877 (0.773–1.005)

0.063

0.289 (0.189–0.443)

 < 0.001

1.026 (1.017–1.035)

 < 0.001

0.999 (0.997–1.002)

0.616

  1. IRR Incidence rate ratio, CI Confidence interval, ART Antiretroviral therapy. Treat-all: June 2016. PLHIV: People living with HIV. Region was divided into Northern China (Hohhot, Shijiazhuang, Beijing and Tianjin), Northeastern China (Dalian and Shenyang), Southern China (Guangzhou and Shenzhen), Southwestern China (Chongqing and Dehong), and Eastern China (Nanjing)