Table 2 Tabular results: pooled chronic phase (CCD)
From: Molecular diagnosis of Chagas disease: a systematic review and meta-analysis
Chronic phase | Summary sensitivity | Summary specificity | Summary DOR (Random effects model) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Study | Sen | 95% CI | TP/(TP + FN) | TN/(TN + FP) | Spe | 95% CI | TP/(TP + FN) | TN/(TN + FP) | DOR | 95% CI | % Weight |
Besuschio, 2017 (b) | 0.533 | 0.266–0.787 | 8/15 | 10/10 | 1.000 | 0.692–1.000 | 8/15 | 10/10 | 23.800 | 1.182–479.070 | 2.06 |
Britto, 1995 | 0.447 | 0.302–0.599 | 21/47 | 124/125 | 0.992 | 0.956–1.000 | 21/47 | 124/125 | 100.150 | 12.891–778.110 | 3.78 |
Carriazo, 1998 | 1.000 | 0.794–1.000 | 16/16 | 10/10 | 1.000 | 0.692–1.000 | 16/16 | 10/10 | 693.000 | 12.749–37,669.400 | 1.24 |
Castro, 2002 | 0.867 | 0.754–0.941 | 52/60 | 9/9 | 1.000 | 0.664–1.000 | 52/60 | 9/9 | 117.350 | 6.237–2208.100 | 2.14 |
De Winne, 2014 (a) | 0.791 | 0.726–0.847 | 148/187 | 85/88 | 0.966 | 0.904–0.993 | 148/187 | 85/88 | 107.520 | 32.248–358.490 | 7.25 |
De Winne, 2014 (b) | 0.690 | 0.618–0.755 | 129/187 | 87/88 | 0.989 | 0.938–1.000 | 129/187 | 87/88 | 193.500 | 26.308–1423.200 | 3.93 |
Deborggraeve, 2009 (b) | 1.000 | 0.872–1.000 | 27/27 | 108/108 | 1.000 | 0.966–1.000 | 27/27 | 108/108 | 11,935.000 | 231.600–615039.200 | 1.27 |
Duartel, 2014 (a) | 0.510 | 0.408–0.611 | 51/100 | 105/105 | 1.000 | 0.965–1.000 | 51/100 | 105/105 | 219.530 | 13.274–3630.400 | 2.31 |
Duarte, 2014 (b) | 0.220 | 0.143–0.314 | 22/100 | 105/105 | 1.000 | 0.965–1.000 | 22/100 | 105/105 | 60.478 | 3.613–1012.200 | 2.29 |
Espinoza, 1996 (a) | 0.941 | 0.713–0.999 | 16/17 | 5/5 | 1.000 | 0.478–1.000 | 16/17 | 5/5 | 121.000 | 4.275–3424.600 | 1.71 |
Espinoza, 1996 (b) | 1.000 | 0.805–1.000 | 17/17 | 5/5 | 1.000 | 0.478–1.000 | 17/17 | 5/5 | 385.000 | 6.807–21776.200 | 1.22 |
Ferrer, 2013 (c) | 0.238 | 0.121–0.395 | 10/42 | 30/30 | 1.000 | 0.884–1.000 | 10/42 | 30/30 | 19.708 | 1.107–350.990 | 2.21 |
Ferrer, 2013 (d) | 0.262 | 0.139–0.420 | 11/42 | 30/30 | 1.000 | 0.884–1.000 | 11/42 | 30/30 | 22.270 | 1.257–394.690 | 2.21 |
Flores-Chavez, 2021 (b) | 0.471 | 0.395–0.548 | 82/174 | 34/34 | 1.000 | 0.897–1.000 | 82/174 | 34/34 | 61.541 | 3.714–1019.700 | 2.30 |
Gil, 2007 | 0.944 | 0.874–0.982 | 84/89 | 62/67 | 0.925 | 0.834–0.975 | 84/89 | 62/67 | 208.320 | 57.788–750.970 | 6.81 |
Gomes, 1999 | 0.835 | 0.735–0.909 | 66/79 | 24/34 | 0.706 | 0.525–0.849 | 66/79 | 24/34 | 12.185 | 4.724–31.430 | 8.90 |
Gutierrez, 2004 | 0.848 | 0.750–0.919 | 67/79 | 24/25 | 0.960 | 0.796–0.999 | 67/79 | 24/25 | 134.000 | 16.531–1086.200 | 3.67 |
Hernández, 2016 (c) | 0.568 | 0.522–0.612 | 273/481 | 138/141 | 0.979 | 0.939–0.996 | 273/481 | 138/141 | 60.375 | 18.965–192.200 | 7.53 |
Hernández, 2016 (d) | 0.642 | 0.598–0.685 | 309/481 | 137/141 | 0.972 | 0.929–0.992 | 309/481 | 137/141 | 61.531 | 22.377–169.200 | 8.46 |
Mayta, 2019 | 0.313 | 0.240–0.394 | 47/150 | 115/115 | 1.000 | 0.968–1.000 | 47/150 | 115/115 | 106.010 | 6.453–1741.000 | 2.32 |
Melo, 2015 | 0.975 | 0.868–0.999 | 39/40 | 20/20 | 1.000 | 0.832–1.000 | 39/40 | 20/20 | 1079.700 | 42.082–27700.000 | 1.80 |
Piron, 2007 (a) | 0.421 | 0.263–0.592 | 16/38 | 144/144 | 1.000 | 0.975–1.000 | 16/38 | 144/144 | 211.930 | 12.279–3657.800 | 2.25 |
Piron, 2007 (b) | 0.421 | 0.263–0.592 | 16/38 | 144/144 | 1.000 | 0.975–1.000 | 16/38 | 144/144 | 211.930 | 12.279–3657.800 | 2.25 |
Ramírez, 2009 (a) | 0.742 | 0.681–0.796 | 178/240 | 20/20 | 1.000 | 0.832–1.000 | 178/240 | 20/20 | 117.100 | 6.978–1964.800 | 2.29 |
Ramírez, 2009 (b) | 0.750 | 0.690–0.803 | 180/240 | 20/20 | 1.000 | 0.832–1.000 | 180/240 | 20/20 | 122.320 | 7.288–2053.200 | 2.29 |
Ramírez, 2015 (c) | 0,841 | 0.772–0.897 | 122/145 | 50/50 | 1.000 | 0.929–1.000 | 122/145 | 50/50 | 526.490 | 31.374–8835.100 | 2.29 |
Ramírez, 2015 (d) | 0.807 | 0.733–0.868 | 117/145 | 50/50 | 1.000 | 0.929–1.000 | 117/145 | 50/50 | 416.400 | 24.934–6953.900 | 2.29 |
Seiringer, 2017 (a) | 1.000 | 0.929–1.000 | 50/50 | 3/3 | 1.000 | 0.292–1.000 | 50/50 | 3/3 | 707.000 | 12.111–41,271.100 | 1.20 |
Seiringer, 2017 (b) | 0.940 | 0.835–0.987 | 47/50 | 3/3 | 1.000 | 0.292–1.000 | 47/50 | 3/3 | 95.000 | 4.047–2229.800 | 1.89 |
Seiringer, 2017 (c) | 0.900 | 0.782–0.967 | 45/50 | 3/3 | 1.000 | 0.292–1.000 | 45/50 | 3/3 | 57.909 | 2.628–1275.800 | 1.96 |
Seiringer, 2017 (d) | 0.980 | 0.894–0.999 | 49/50 | 3/3 | 1.000 | 0.292–1.000 | 49/50 | 3/3 | 231.000 | 7.871–6779.400 | 1.68 |
Viettri, 2022 (c) | 0.848 | 0.681–0.949 | 28/33 | 61/61 | 1.000 | 0.941–1.000 | 28/33 | 61/61 | 637.360 | 34.070–11923.600 | 2.15 |
Viettri, 2022 (d) | 0.909 | 0.757–0.981 | 30/33 | 61/61 | 1.000 | 0.941–1.000 | 30/33 | 61/61 | 1071.900 | 53.642–21,417.600 | 2.07 |
Pooled | 0.670 | 0.654–0.685 | 0.985 | 0.978–0.990 | 110.730 | 69.476–176.480 | |||||
No. studies | 33 | 33 | 33 | ||||||||
Heterogeneity (Chi-squared) | 663.02 (df = 32) | 91.13 (df = 32) | 42.80 (df = 32) | ||||||||
P-value | 0.000 | 0.000 | 0.096 | ||||||||
Inconsistency (I-square) | 95.2% | 64.9% | 25.2% | ||||||||
Estimate of between-study variance (Tau-squared) | 0.4021 | ||||||||||