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Table 3 Effect of Bm-ipgm gene silencing on adult male and female B. malayi

From: In vitro gene silencing of independent phosphoglycerate mutase (iPGM) in the filarial parasite Brugia malayi

  Motility score (female worms) % Inhibition in MTT reduction Motility score *(male worms) % Inhibition in MTT reduction
Time( hr) Control Negative siRNA Gene specific siRNA Negative siRNA Gene specific siRNA Control Negative siRNA Gene specific siRNA Negative siRNA Gene specific siRNA
12 5 5 4 2.25 ± 3.3 29.9 ± 5.4 5 5 4 2.5 ± 1.3 26.8 ± 4.5
24 5 5 3 4.5 ± 1.2 40.2 ± 6.2 5 5 3 4.5 ± 1.3 38.8 ± 6.5
36 4 5 3 5.0 ± 2.3 55.4 ± 6.3 4 4 2 4.5 ± 2.6 64.4 ± 5.4
48 4 4 2 6.2 ± 2.8 74.4 ± 3.4 4 4 1 6 ± 1.8 80.2 ± 6.8
108 4 4 2 6.26 ± 2.3 75.9 ± 4.7 4 4 1 5.25 ± 2.6 89.4 ± 5.3
  1. Key: *0%: 5; 1 to 25%: 4; 26 to 49%: 3; 50 to 74%: 2; 75-99%: 1; 100%: Dead.