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Table 2 Characteristics of the included studies

From: Community-based interventions for the prevention and control of helmintic neglected tropical diseases

Study Study design Country Intervention Target population Integrated/Non-Integrated
Adam 1995 [13] RCT Kenya Three doses of 400 mg ALB vs. identical placebo on three consecutive school days Children aged 5–10 years infected with hookworms or ascariasis School-based
Ageel 1997 [33] Pre/post Saudi Arabia One oral dose of PZQ (40 mg/kg) + snail/vector control + health education + community participation General population infected with schistosomiasis PHC
Albonico 2002 [14] RCT Tanzania MBZ 500 mg vs. pyrantel-oxantel (10 mg/kg) vs. placebo Children aged 6–9 years School-based
Bausch 1995 [35] Quasi Cameroon Health education + PZQ Children aged 5–15 years with schistosomiasis PHC + school-based
Beasely 1999 [25] RCT Tanzania Single dose of 400 mg ALB + PPZQ (40 mg/kg) vs. placebo Infected children aged 7–12 years Non-integrated
Bhargawa 2003 [15] RCT Tanzania ALB 400 mg + PZQ single 40 mg/kg vs. placebo Infected children aged 9–15 years School-based
Christian 2009 [36] RCT Nepal ALB 40 mg in 2nd + 3rd trimester Pregnant women Integrated with routine ANC
Dossa 2001 [26] RCT Benin Iron (Fe) (60 mg/day) + ALB (200 mg for 3 days) vs. FE + placebo vs. ALB + placebo vs. placebo 10 months F/V Children aged 3–5 years Non-integrated
Engels 1993 [11] Pre/post Burundi Single dose PZQ (40 mg/kg), 50–150 mg levamisole or 500 mg MBL or PZQ (20 mg/kg) + snail vector control + education General population PHC
Gryseels 1991 [23] Pre/post Burundi PZQ (40 mg/kg) General population Non-integrated
Gundersen 1990 [34] Pre/post Ethiopia Vector snail control + 20 mg oxamniquine followed by 40 mg the next day General population PHC
Guyatt 2001 [16] Pre/post Tanzania Single dose 400 mg ALB + PZQ 40 mg/kg School children aged 8–14 years School-based
Halwindi 2011 [27] RCT Zambia Facility vs. community detected and treatment + training + education + MBZ Children aged 12–months (preventive) Non-integrated
Haque 2010 [28] RCT Bangladesh 400 mg ALB + B-carotene (2 doses) vs. ALB + placebo vs. B-carotene + placebo vs. placebo + placebo Infected children aged 24–60 months Non-integrated
Hathirat 1992 [24] RCT Thailand Fe 50 mg FeSo 4 daily for 2 weeks then 100 mg for 14wks vs. anthelminthic Children aged 9–11 years School-based
Kosinski 2012 [31] Pre/post Ghana Water recreation area + PZQ Children Non-integrated
Koukounari 2006 [17] Pre/post Uganda PZQ Children aged 7–14 years School-based
Koukounari 2007 [18] Pre/post Burkina Faso PZQ 40 mg/kg + ALB 400 mg Children aged 6–14 years School-based
Larocque 2006 [37] RCT Peru MBZ 500 mg single dose + 60 mg FE daily vs. placebo + FE Pregant women aged 18–44 years in the 2nd trimester Integrated with routine ANC
Ndibazza 2010 [38] RCT Uganda ALB (400 mg) vs. PZQ 40 mg/kg vs. ALB + PZQ vs. placebo Pregnant women Integrated with routine ANC
Nsowah-Nuamah 2001 [12] Pre/post Ghana PZQ 40 mg/kg + passive edu vs. PZQ + no education vs. PZQ + active edu vs. community mobilization Those aged 5 years and above Non-integrated
Olds 1999 [29] RCT China and Philippines ALB + PZQ vs. PZQ + ALB placebo vs. ALB + PZQ placebo vs. placebo + placebo Infected school aged children (4–18 years) Non-integrated
Palupi 1997 [30] RCT Indonesia FE + ALB 400 mg once a week vs. FE once a week + placebo vs. placebo alone Children aged 2–5 years Non-integrated
Phuc 2009 [40] Pre/post Vietnam IEC materials + staff training + Ferrous Sulphate/ folic acid (200 mg) + ALB (400 mg) Women of reproductive age (16–45 years) Non-integrated
Rohner 2010 [19] RCT Cote d’Ivoire Iron fortified biscuits (20 mg fe/day) + IPT-SP (500 mg sulphadoxine + 25 mg pyrimethamine) + anthelminthic (400 mg-single) + PZQ (single – 40 mg/kg) in different combinations School children aged 6–14 years School-based
Savioli 1989 [9] Pre/post Tanzania PZQ Children School-based
Sungthong 2002 [20] RCT Thailand Deworming (400 mg ALB single) + daily or weekly iron Children aged 6–13 years School-based
Sinoun 2007 [10] Pre/post Cambodia Universal chemotherapy with PZQ (40 mg/kg) General population Non-integrated
Taylor 2001 [21] RCT South Africa ALB (400 mg) + PZQ (40 mg/kg) + FE fumigate 200 mg weekly vs. ALB (400 mg) + PZQ (40 mg/kg) + placebo weekly vs. ALB (400 mg) daily + PZQ (40 mg/kg) + FE 200 mg weekly vs. ALB (400 mg) + PZQ (40 mg/kg) + placebo weekly vs. placebos + FE 200 mg weekly vs. placebos Children aged 6–15 years School-based
Torlesse 2001 [39] RCT Sierra Leone FE + ALB vs. FE alone vs. ALB alone vs. placebo Pregnant women (10–14 weeks) Integrated with routine ANC
Wang 2009 [32] Quasi China Health education + vector control + removing cattle + latrines + PZQ General population Non-integrated
Zhang 2007 [22] Pre/post Uganda PZQ (40 mg/kg) + ALB(400 mg) + education School children and adults Non-integrated