Regimen | Oral1 | Intravenous4 |
---|---|---|
Central venous line | Not required | Required |
Interferon-beta | 6 million international units (MIU) prefilled pen via intramuscular injection (IMI) weekly for 3Â weeks.2 | 6 MIU intravenous infusion over 2Â hour daily for up to 3Â weeks3 or 6 MIU prefilled pen IMI weekly for 3Â weeks. |
Amiodarone | 600Â mg p.o. twice daily for 8Â days (loading) then maintenance 600Â mg p.o. daily for further 3Â weeks. | 150Â mg into 100Â ml D5 over 10Â minutes followed by 360Â mg infusion over 6Â hours then 540Â mg infusion over 18Â hours D1.4 Amiodarone 720Â mg infusion daily or 600Â mg p.o. twice daily for further 7Â days followed by 600Â mg p.o. maintenance daily for further 3Â weeks. |
Toremifene | 800Â mg p.o. on Day 1 (loading) then 400Â mg p.o. daily.5 | 800Â mg p.o. on Day 1 (loading) then 400Â mg p.o. daily.5 |
Favipiravir | 1800Â mg p.o. twice daily on Day 1 (loading doses) then 800Â mg p.o. twice daily.6 | 1800Â mg p.o. twice daily on Day 1 (loading doses) then 800Â mg p.o. twice daily. |