Praziquantel efficacy against Schistosoma mansoni among HIV-1 infected and uninfected adults living in fishing villages along Lake Victoria, Northwest Tanzania

Mazigo, Humphrey D; Dunne, David W; Kinung’hi, Safari M; Nuwaha, Fred

doi:10.1186/2049-9957-3-47

Table 2 Schistosoma mansoni geometrical mean egg per gram of faeces (GM-epg) after praziquantel treatment in relation to demographic factors and S. mansoni infection intensities

From: Praziquantel efficacy against Schistosoma mansoni among HIV-1 infected and uninfected adults living in fishing villages along Lake Victoria, Northwest Tanzania

*Variable*	*Baseline before treatment*				*12 weeks after treatment*
	N	GM-epg	95% CI	P-values	N	GM-epg	95% CI	P-values
Overall	555	174.21	154.14–196.87		212	39.88	36.77–43.25
Sex
Female	241	130.36	110.60–153.66	0.0001*	119	128.19	99.33–165.43	0.01
Male	314	217.41	183.01–258.29		93	222.37	168.53–293.41	0.01
Age group
21–30	241	198.67	163.49–241.42	0.25**	92	37.53	33.07–42.58	0.36**
31–40	177	156.18	126.12–193.41		74	43.95	38.14–50.66
41–50	84	164.09	125.66–214.26		25	33.63	28.48–39.71
51–60	53	152.13	98.56–234.79		21	45.30	33.83–60.66
Occupation
Small-scale business	66	136.05	99.65–185.74	0.08**	27	35.81	28.97–44.26	0.89**
Farming	376	157.92	135.73–183.74		141	39.58	35.71–43.88
Fishing	113	278.74	214.63–362.00		44	43.65	36.72-51.88
Village of residence
Igombe	112	139.77	109.22–178.86	0.09**	45	36.28	31.16–42.24	0.38**
Igalagala	98	215.61	158.21–293.83		45	42.51	35.35–51.12
Kayenze	219	197.91	162.96–240.35		78	41.12	35.58–47.52
Sangabuye	126	144.04	110.22–188.24		44	38.99	32.51–46.76
Time of residence (years)
3–5	97	188.36	142.36–249.22	0.43**	33	43.18	34.74–53.67	0.66**
6–10	83	156.69	113.85–215.65		30	35.88	29.56–43.54
11–20	136	204.77	159.53–262.83		52	41.16	35.20–48.14
≥21	239	159.82	132.07–193.39		97	39.44	34.68–44.84
HIV-1 serostatus
Negative	526	175.06	154.48–198.39	0.56*	197	39.88	36.69–43.35	0.22*
Positive	29	159.39	86.09–295.14		15	39.85	27.20–58.41
CD4 ⁺ count levels (cells/μL)
<350	17	134.59	52.19–347.07	0.75*	11	49.66	27.16–90.79	0.16*
>350	12	215.78	80.79–576.36		4	31.59	13.18–75.69
*Schistosoma mansoni* infection intensities (epg)
Light (1–100 epg)	234	44.43	41.36–47.72	0.0001**	92	30.89	28.49–33.49	0.0001**
Moderate (101–399 epg	162	199.39	188.32–211.12		56	42.85	37.47–49.01
Heavy (≥400 epg)	159	1124.33	987.62–1277.36		64	54.07	44.81–65.25

P- values= t-test* and ANOVA**.

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ISSN: 2049-9957

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