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Table 5 Behavioural and clinical factors associated with virologic failure and risk estimates

From: Immuno-haematologic and virologic responses and predictors of virologic failure in HIV-1 infected adults on first-line antiretroviral therapy in Cameroon

Factors Behavioural Virologic responses: prevalence, n (%) Risk estimates (95% CI)
  N VF AS p-value Crude odd ratio Adjusted odd ratio p-value
Alcohol:        
 Yes 313 65 (20.8) 248 (79.2) 0.927 0.98 (0.66-1.46)   
 No 280 59 (21.1) 221 (78.9)   1   
Smoking:        
 Yes 55 15 (27.3) 40 (72.7) 0.223 1.48 (0.79-2.77)   
 No 538 109 (20.3) 429 (79.7)   1   
Clinical history        
Duration of ART        
 (months): ≤ 12 108 48 (44.4) 60 (55.6) < 0.001 4.24 (2.49-7.23) 1.11 (0.40-3.16) 0.851
 12-36 361 76 (21.1) 285 (78.9)   1.41 (0.90-2.22) 1.57 (0.73-3.36) 0.251
 > 36 208 33 (15.9) 175 (84.1)   1 1  
Regimen type:        
 EFV-based 177 35 (19.8) 142 (80.2) 0.232 0.77 (0.51-1.18)   
 NVP-based 492 119 (24.2) 373 (75.8)   1   
Co-infection status:        
 HIV/TB co-infected 51 22 (45.1) 28 (54.9) < 0.001 3.24 (1.80-5.84) 0.20 (0.04-0.70) 0.014
 HIV only 589 119 (20.2) 470 (79.8)   1 1  
CD4+T-cell (cells/μL):        
 < 200 154 46 (29.9) 108 (70.1) 0.002 2.49 (1.0-6.31) 0.68 (0.23-2.05) 0.497
 200 - 499 165 24 (14.5) 141 (85.5)   1.69 (0.63-4.49) 1.22 (0.40-3.75) 0.724
 ≥ 500 41 06 (14.6) 35 (85.4)   1 1  
Anaemic status (g/dL):        
 Anaemic 114 34 (29.8) 80 (70.2) < 0.001 2.48 (1.52-4.07) 2.30 (1.10-4.83) 0.028
 Non-anaemic 376 55 (14.6) 321 (85.4)   1 1  
  1. VF: Virologic failure (viral load > 400 RNA copies/mL after ≥ 6 months of ART), AS: Adequate suppression (≥ 400 RNA copies/mL after ≥ 6 months of ART), Anaemia: Hgb < 11 g/dl, CI - confidence interval.