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Table 1 Artemisinins and other antimalarials

From: Development of antimalarial drugs and their application in China: a historical review

Drug Date of discovery or creation Initial action in parasite Cross- resistance to CQ* Half-life (h) Route of administration for treatment Reference
Artemisinin 1973 Membrane system, on membrane of food vacuoles etc. Low 0.5–0.7 po [5, 810]
Artemether 1976 Ditto 0.90 ± 0.37 po, im [8, 11, 18]
Artesunate 1977 Ditto 0.6–0.8 po, im, iv [23, 24]
Dihydroartemisinin 1976 Ditto 2.6 po [11, 27]
Piperaquine 1965 Food vacuoles Possession 216 po [3032]
Pyronaridine 1970 1. Food vacuoles Without 65,251** po, im, iv drip [3845]
   2. Pellicular complexes     
Benflumetol 1976 *** *** 47.4 po [51, 52]
Naphthoquine 1981 Membrane system Possession 41–57 po [56]
  1. *The tests were against P. berghei in mice. CQ: chloroquine.
  2. **By different methods.
  3. ***The initial action and cross-resistance of the drug were reported to be similar to those of mefloquine.