Figure 3

Accumulative plasma levels of Miglustat and Clomiphene (Toremifene) of different dosages and administration intervals in primates: For Miglustat, three conditions are calculated: 250 mg each at an interval of 12 hours (equal to the dosage and the interval for the mouse model); 200 mg each at an interval of 8 hours (the maximum dosage and the normal interval for humans); 100 mg each at an interval of 4 hours (as suggested here). Plasma level of 250 mg/day Clomiphene (injection) is approximately equal to that of 600 mg/day Toremifene (oral administration). Grey line indicates the supposed plasma level after single drug administration. Red line or blue line shows the calculated accumulative plasma levels of each drug. Purple line marks the concentration for effective EBOV inhibition as indicated in cell culture assay. h, hours. d, days.