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Table 3 Clinical characteristics of study subjects at baseline, 2nd, 5th and 6th months of anti-TB treatment period, September 2013- March 2015

From: Diabetes mellitus is associated with increased mortality during tuberculosis treatment: a prospective cohort study among tuberculosis patients in South-Eastern Amahra Region, Ethiopia

Months of anti-TB therapy
Clinical symptoms Baseline (n = 1314)a 2nd month (n = 1283)a 5th month (n = 1246)a 6th month (n = 1229)a
  TBNDM
n (%)
TBDM
n (%)
P-value TBNDM
n (%)
TBDM
n (%)
P-value TBNDM
n (%)
TBDM
n (%)
P-value TBNDM
n (%)
TBDM
n (%)
P-value
Cough 784 (65.1) 79 (72.5) 0.12 166 (14.0) 23 (23.0) 0.02 24 (2.1) 2 (2.2) 1.00* 18 (1.6) 2 (2.2) 0.66*
Fever 933 (78.4) 80 (73.4) 0.34 166 (14.0) 18 (18.0) 0.28 29 (2.5) 2 (2.2) 1.00* 13 (1.1) 1 (1.1) 1.00*
Hemoptysis 228 (18.9) 24 (22.0) 0.43 18 (1.5) 6 (6.0) 0.008 4 (0.3) - - 1 (0.1) - -
Weight loss 949 (78.8) 94 (86.2) 0.06 86 (7.3) 14 (14.0) 0.02 14 (1.2) 2 (2.2) 0.34* 10 (0.9) 1 (1.1) 0.58*
Poor appetite 922 (76.5) 86 (78.9) 0.57 154 (13.0) 16 (16.0) 0.39 25 (2.2) 2 (2.2) 1.00* 10 (0.9) - -
Night sweat 818 (67.9) 75 (68.8) 0.84 121 (10.2) 6 (6.0) 0.17 21 (1.8) 2 (2.2) 0.69* 14 (1.2) 2 (2.2) 0.34*
Dyspnea 587 (48.7) 52 (47.7) 0.84 93 (7.9) 9 (9.0) 0.68 24 (2.1) 2 (2.2) 1.00* 9 (0.8) 2 (2.2) 0.20*
Chest pain 683 (56.7) 64 (58.7) 0.68 108 (9.1) 9 (9.0) 0.96 26 (2.3) 4 (4.3) 0.27* 9 (0.8) 2 (2.2) 0.20*
Fatigue 967 (80.2) 90 (82.6) 0.56 207 (17.5) 29 (29.0) 0.004 46 (4.0) 5 (5.4) 0.42* 21 (1.8) 3 (3.2) 0.42*
BMI (kg/m2)             
<18.5 720 (69.5) 59 (54.1)   567 (47.9) 48 (48.0)   424 (36.8) 37 (39.8)   377 (33.2) 33 (35.5)  
18.5–24.9 445 (36.9) 44 (40.4)   583 (49.3) 42 (42.0)   686 (59.5) 48 (51.6)   713 (62.8) 51 (54.8)  
≥25 31 (2.6) 6 (5.5) 0.13* 33 (2.8) 10 (10.0) 0.002* 42 (3.6) 8 (8.6) 0.05* 46 (4.0) 9 (9.7) 0.04*
Mean (± SD) 18.05 (±2.94) 18.35(±3.72) 0.31 18.95 (±5.79) 21.29 (±20.46) 0.005 19.55 (±3.50) 19.98 (±3.86) 0.26* 19.78 (±2.87) 20.58 (±4.95) 0.02
  1. TB: tuberculosis, TBNDM: TB without DM, TBDM: TB and DM, BMI: body mass index, kg: kilogram, m 2: meter square, SD: standared deviation
  2. *Fisher’s exact test
  3. athe number of total patients