Table 2 Key amino acid residues analysis of A/environment/Jiangxi/26/2009(H11N9) and A/environment/Jiangxi/28/2009(H11N9)
Protein | Mutation | Function | JX/26/2009 and JX/28/2009 |
|---|---|---|---|
HA | Q226L | Receptor biding site. Q is the avian signature. | Q |
PB2 | E627K | Enhances pathogenicity in mice | E |
D701N | D | ||
M1 | N30D | increase the virulence of H5N1 avian influenza viruses in mice | D |
T215A | A | ||
M2 | S31N | resist to amantadine | S |
H274Y | H | ||
NA | E119V | resist to oseltamivir or zanamivir | E |
R152K | R |