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Table 3 Unadjusted mediating effects of BMI and WC on the association between HAART and blood pressure (N = 406)

From: Impact of body fat changes in mediating the effects of antiretroviral therapy on blood pressure in HIV-infected persons in a sub-Saharan African setting

Mediator variable

Predictor variable

Outcome variable

Path A

Path B

Path C’

Path AB

% mediated

Coefficient (95 % CI)

Coefficient (95 % CI)

Coefficient (95 % CI)

Coefficient (95 % CI)

BMI

HAART

Systolic BP

1.16 (0.16 to 2.16)

1.11 (0.70 to 1.52)

8.28 (4.15 to 12.41)

1.29 (0.37 to 2.70)

14

Diastolic BP

1.16 (0.16 to 2.16)

0.62 (0.42 to 0.83)

6.77 (4.65 to 8.88)

0.73 (1.01 to 1.35)

10

WC

HAART

Systolic BP

3.42 (0.92 to 5.92)

0.39 (0.23 to 0.56)

7.96 (3.86 to 12.06)

1.35 (0.24 to 2.76)

15

Diastolic BP

3.42 (0.92 to 5.92)

0.26 (0.17 to 0.34)

6.71 (4.60 to 8.81)

0.87 (0.17 to 1.69)

12

Combined BMI/WC

HAART

Systolic BP

4.36 (0.85 to 7.89)

1.01 (0.24 to 1.78)

8.15 (4.08 to 12.23)

1.51 (0.28 to 3.15)

16

Diastolic BP

4.36 (0.85 to 7.89)

0.54 (0.15 to 0.94)

6.87 (4.79 to 8.95)

0.95 (0.19 to 2.24)

12

  1. Path A – regression coefficient for the independent variable when the mediator variable is regressed on the independent variable
  2. Path B – regression coefficient for the mediator variable when the dependent variable is regressed on the mediator variable, adjusted for the independent variable
  3. Path C – the direct effect of the independent variable on the dependent variable
  4. Path AB – the indirect effect of the independent variable on the dependent variable through the mediator variable
  5. % mediated – the amount (in percentage) of the total effect of the independent variable on the dependent variable that is attributed indirectly to the mediator variable
  6. NS – not statistically significant at 5 % level; all other coefficients were statistically significant
  7. 95 % confidence intervals for indirect effects (Path AB) are bias-corrected
  8. Abbreviations: BMI body mass index, CI confidence interval, HAART highly active antiretroviral therapy, WC waist circumference