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Table 5 Therapeutic outcomes based on age group in children treated with artesunate-amodiaquine

From: Therapeutic efficacy and effects of artesunate-amodiaquine and artemether-lumefantrine on malaria-associated anaemia in Nigerian children aged two years and under

Parameter ≤2 years <5 years
<1 year (n = 29) ≥1 year (n = 91) P value ≤2 years (n = 120) ≥2– < 5 years (n = 315) P value
Haematocrit (%)
 Mean 28.8 28.4 0.63 28.5 30.5 <0.0001
 95 % CI 27.4–30.3 27.2–29.5 27.6–29.4 30–31.1
 No <30 % 13 55 0.21 68 117 <0.0001
Parasitaemia (μL−1)
 Geometric mean 13,807 11,883 0.55 12,322 23,733 <0.0001
 Range 1,018–114,504 1,000–128,976 1,000–128,976 1,000–1,125,000
 No. >100,000 μL−1 2 7 1.0 9 55 0.01
 No. >250,000 μL−1 0 0 - 0 12 -
 ACPR on day 28 (%) 26/27 (96) 86/89 (97) 1.0 112/116 (97) 294/310 (95) 0.48
 Parasite prevalence on day 1 (%) 18 (62) 40 (44) 0.14 58 (48) 124 (39) 0.11
PRRD1
 Geometric mean 3.8 × 102 6.4 × 102 0.41 5.4 × 102 1.9 × 103 0.001
 Range 3.9 × 100–1.1 × 105 1.1 × 10−1–1.3 × 105 1.1 × 10−1–1.3 × 105 3.2 × 10−1–1.1 × 106
PRRD2
 Geometric mean 1.0 × 104 1.0 × 104 0.56 1.0 × 104 1.9 × 104 0.001
 Range 3.9 × 101–1.1 × 105 9.5 × 101–1.3 × 105 1.9 × 101–1.3 × 105 5.3 × 101–1.1 × 106
 Parasite positivity rate on day 3 0 3 - 2 2 0.31
Fever clearance time (day)
 Mean 1.3 1.3 0.79 1.3 1.1 0.005
 95 % CI 1–1.6 1–1.7 1.1–1.5 1–1.1
 Parasite clearance time (day)
 Mean 1.7 1.5 0.06 1.5 1.4 0.11
 95 % CI 1.5–1.9 1.4–1.6 1.4–1.6 1.4–1.5
Anaemia recovery time (day)
 Mean 12.1 12.5 0.91 12.4 10.4 0.12
 95 % CI 6–18.2 9.9–15.1 10.1–14.7 9–11.8
  1. ACPR adequate clinical and parasitological response, PRR D1 parasite reduction ratio 1 day after treatment started, PRR D2 parasite reduction ratio 2 days after treatment started