|
Parameter
|
≤2 years
|
<5 years
|
|---|
|
<1 year (n = 29)
|
≥1 year (n = 91)
|
P value
|
≤2 years (n = 120)
|
≥2– < 5 years (n = 315)
|
P value
|
|---|
|
Haematocrit (%)
|
|
Mean
|
28.8
|
28.4
|
0.63
|
28.5
|
30.5
|
<0.0001
|
|
95 % CI
|
27.4–30.3
|
27.2–29.5
|
27.6–29.4
|
30–31.1
|
|
No <30 %
|
13
|
55
|
0.21
|
68
|
117
|
<0.0001
|
|
Parasitaemia (μL−1)
|
|
Geometric mean
|
13,807
|
11,883
|
0.55
|
12,322
|
23,733
|
<0.0001
|
|
Range
|
1,018–114,504
|
1,000–128,976
|
1,000–128,976
|
1,000–1,125,000
|
|
No. >100,000 μL−1
|
2
|
7
|
1.0
|
9
|
55
|
0.01
|
|
No. >250,000 μL−1
|
0
|
0
|
-
|
0
|
12
|
-
|
|
ACPR on day 28 (%)
|
26/27 (96)
|
86/89 (97)
|
1.0
|
112/116 (97)
|
294/310 (95)
|
0.48
|
|
Parasite prevalence on day 1 (%)
|
18 (62)
|
40 (44)
|
0.14
|
58 (48)
|
124 (39)
|
0.11
|
|
PRRD1
|
|
Geometric mean
|
3.8 × 102
|
6.4 × 102
|
0.41
|
5.4 × 102
|
1.9 × 103
|
0.001
|
|
Range
|
3.9 × 100–1.1 × 105
|
1.1 × 10−1–1.3 × 105
|
1.1 × 10−1–1.3 × 105
|
3.2 × 10−1–1.1 × 106
|
|
PRRD2
|
|
Geometric mean
|
1.0 × 104
|
1.0 × 104
|
0.56
|
1.0 × 104
|
1.9 × 104
|
0.001
|
|
Range
|
3.9 × 101–1.1 × 105
|
9.5 × 101–1.3 × 105
|
1.9 × 101–1.3 × 105
|
5.3 × 101–1.1 × 106
|
|
Parasite positivity rate on day 3
|
0
|
3
|
-
|
2
|
2
|
0.31
|
|
Fever clearance time (day)
|
|
Mean
|
1.3
|
1.3
|
0.79
|
1.3
|
1.1
|
0.005
|
|
95 % CI
|
1–1.6
|
1–1.7
|
1.1–1.5
|
1–1.1
|
|
Parasite clearance time (day)
|
|
Mean
|
1.7
|
1.5
|
0.06
|
1.5
|
1.4
|
0.11
|
|
95 % CI
|
1.5–1.9
|
1.4–1.6
|
1.4–1.6
|
1.4–1.5
|
|
Anaemia recovery time (day)
|
|
Mean
|
12.1
|
12.5
|
0.91
|
12.4
|
10.4
|
0.12
|
|
95 % CI
|
6–18.2
|
9.9–15.1
|
10.1–14.7
|
9–11.8
|
-
ACPR adequate clinical and parasitological response, PRR
D1
parasite reduction ratio 1 day after treatment started, PRR
D2
parasite reduction ratio 2 days after treatment started
