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Table 7 Features of ≤ 2 years old children who developed anaemia after day 14

From: Therapeutic efficacy and effects of artesunate-amodiaquine and artemether-lumefantrine on malaria-associated anaemia in Nigerian children aged two years and under

Patient (gender, age) Year of enrolment Parasitaemia (μL−1) Enrolment HCT (%) Antimalarial treatment PCT (day) Nadir HCT (%) [day] Time of LAA (day) LAnRT Parasite reduction ratio (PRR) Total of mg/kg dose of AA Total of mg/kg dose of AL
Day 1 Day 2 Artesunate Amodiaquine Artemether Lumefantrine
124 (M, 2y) 2010 12,648 25 AL 2 28 [28] 28 NAc 1.2 × 101 1.3 × 104 NA NA 10.9 65.5
15 (M, 1.2y) 2008 72,815 27 AL 1 28 [28] 21 14 7.3 × 104 7.3 × 104 NA NA 17.4 102
46 (M, 0.8y) 2015 16,979 27 AA 1 29 [21] 21 7 1.7 × 104 1.7 × 104 15 40.5 NA NA
58 (M, 2y) 2010 19,647 28 AL 4 28 [28] 28 NAc 7.6 × 100 2.5 × 102 NA NA 8.6 51.4
15 (M, 1y) 2014 29,714 30 AL 1 29 [28] 28 7 3.0 × 104 3.0 × 104 NA NA 8.6 51.4
100 (M, 1.3y) 2010 118,344 30 AL 2 29 [21] 21 7 3.5 × 101 1.2 × 105 NA NA 13.3 80
64 (F, 1.9y)a 2010 76,000 30 AA 2 29 [28] 28 NAc 5.5 × 101 7.6 × 104 14.3 38.6 NA NA
8 (F, 1y) 2010 25,242 30 AA 2 28 [28] 28 NAc 2.4 × 102 2.5 × 104 10.7 28.9 NA NA
40 (F, 2y) 2010 1,652 30 AA 1 28 [21] 21 7 1.7 × 103 1.7 × 103 9.4 25.3 NA NA
911 (M, 1.9y) 2011 2,924 30 AA 1 28 [21] 21 14 2.9 × 103 2.9 × 103 12.5 38.3 NA NA
43 (M, 1.3y) 2010 1,301 31 AL 1 27 [28] 21 NAc 1.3 × 103 1.3 × 103 NA NA 13.3 80
Mean
Age (1.5y)   15,569b 28.9   1.6 28.3 24.2 9.3 6.6 × 102 1.0 × 104 12.4 34.3 12 71.7
  1. HCT haematocrit, PCT parasite clearance time, M male, F female, AA artesunate-amodiaquine, AL artemether-lumefantrine, LAA late-appearing anaemia, LAnRT time to recovery from late-appearing anaemia, NA not applicable
  2. achild with fever of 39.5 °C on day 28
  3. bGeometric mean parasitaemia
  4. cfollow up was limited to 28 days