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Table 7 Features of ≤ 2 years old children who developed anaemia after day 14

From: Therapeutic efficacy and effects of artesunate-amodiaquine and artemether-lumefantrine on malaria-associated anaemia in Nigerian children aged two years and under

Patient (gender, age)

Year of enrolment

Parasitaemia (μL−1)

Enrolment HCT (%)

Antimalarial treatment

PCT (day)

Nadir HCT (%) [day]

Time of LAA (day)

LAnRT

Parasite reduction ratio (PRR)

Total of mg/kg dose of AA

Total of mg/kg dose of AL

Day 1

Day 2

Artesunate

Amodiaquine

Artemether

Lumefantrine

124 (M, 2y)

2010

12,648

25

AL

2

28 [28]

28

NAc

1.2 × 101

1.3 × 104

NA

NA

10.9

65.5

15 (M, 1.2y)

2008

72,815

27

AL

1

28 [28]

21

14

7.3 × 104

7.3 × 104

NA

NA

17.4

102

46 (M, 0.8y)

2015

16,979

27

AA

1

29 [21]

21

7

1.7 × 104

1.7 × 104

15

40.5

NA

NA

58 (M, 2y)

2010

19,647

28

AL

4

28 [28]

28

NAc

7.6 × 100

2.5 × 102

NA

NA

8.6

51.4

15 (M, 1y)

2014

29,714

30

AL

1

29 [28]

28

7

3.0 × 104

3.0 × 104

NA

NA

8.6

51.4

100 (M, 1.3y)

2010

118,344

30

AL

2

29 [21]

21

7

3.5 × 101

1.2 × 105

NA

NA

13.3

80

64 (F, 1.9y)a

2010

76,000

30

AA

2

29 [28]

28

NAc

5.5 × 101

7.6 × 104

14.3

38.6

NA

NA

8 (F, 1y)

2010

25,242

30

AA

2

28 [28]

28

NAc

2.4 × 102

2.5 × 104

10.7

28.9

NA

NA

40 (F, 2y)

2010

1,652

30

AA

1

28 [21]

21

7

1.7 × 103

1.7 × 103

9.4

25.3

NA

NA

911 (M, 1.9y)

2011

2,924

30

AA

1

28 [21]

21

14

2.9 × 103

2.9 × 103

12.5

38.3

NA

NA

43 (M, 1.3y)

2010

1,301

31

AL

1

27 [28]

21

NAc

1.3 × 103

1.3 × 103

NA

NA

13.3

80

Mean

Age (1.5y)

 

15,569b

28.9

 

1.6

28.3

24.2

9.3

6.6 × 102

1.0 × 104

12.4

34.3

12

71.7

  1. HCT haematocrit, PCT parasite clearance time, M male, F female, AA artesunate-amodiaquine, AL artemether-lumefantrine, LAA late-appearing anaemia, LAnRT time to recovery from late-appearing anaemia, NA not applicable
  2. achild with fever of 39.5 °C on day 28
  3. bGeometric mean parasitaemia
  4. cfollow up was limited to 28 days