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Table 3 Impact of rotavirus vaccination on hospitalisation and mortality due to diarrhoea in Latin America

From: Effectiveness of rotavirus vaccines against rotavirus infection and hospitalization in Latin America: systematic review and meta-analysis

Study Country Vaccine Outcome Pre-vaccination Post-vaccination Difference (%)
Diarrhoea mortality     Year Results Year Results  
do Carmo 2011 [7] Brazil RV1 Annual death rates/100 000 children 2002–2005 <1 yr: 48 2007–2009 <1 yr: 35 −22
1 yr: 11   1 yr: 7 −28
2–4 yr: 1   2–4 yr: 1 −4
All: 12   All: 9 −22
Gurgel 2011 [45] Brazil RV1 Number of hospitalisation 2002–2005 <1 yr: 986 2006–2009 <1 yr: 449 −54.5
1–4 yr: 237   1–4 yr: 159 −32.9
All: 1 223   All: 608 −50.3
Lanzieri 2011 [46] Brazil RV1 Annual death rates/100 000 children 2004–2005 <1 yr: 56.9 2008 <1 yr: 34.9 −39
1–4 yr: 4.5   1–4 yr: 3.0 −33
Richardson 2010 [49] Mexico RV1 Annual death rates/100 000 children 2003–2006 <1 yr: 61.5 2008 <1 yr: 25.5 −41
1–2 yr: 21.1   1–2 yr: 6.1 −29
2–5 yr: 2.9   2–5 yr: 0.2 −7
All: 18.1   All: 6.3 −35
Gastañaduy 2013 [50] Mexico RV1 Annual death rates/100 000 children 2003–2006 <1 yr: 59.1 2009–2011 <1 yr: 28.4 −52
1–2 yr: 19.6   1–2 yr: 7.9 −60
2–5 yr: 2.8   2–5 yr: 2 −26
All: 17   All: 8.5 −50
Bayard 2012 [53] Panama RV1 Annual death rates/100 000 children 2000–2005 <1 yr: 73 2008 <1 yr: 40 −45
1–4 yr: 20.3   1–4 yr: 9 −54
All: 31.1   All: 15.5 −50
Diarrhoea hospitalisation        
do Carmo 2011 [7] Brazil RV1 Hospitalisation rates/100 000 children 2002–2005 <1 yr: 2 477 2007–2009 <1 yr: 1 840 −25
1 yr: 2 487   1 yr: 1 886 −21
2–4 yr: 774   2–4 yr: 722 −7
All: 1 429   All: 1 165 −17
Gurgel 2011 [45] Brazil RV1 Number of hospitalisation 2002–2005 <1 yr: 194 348 2006–2009 <1 yr: 125 151 −35.6
1–4 yr: 301 479   1–4 yr: 264 376 −12.3
All: 495 827   All: 389 527 −21.4
Masukawa 2014 [47] Brazil RV1 Hospitalisation rates/100 000 children 2000–2005 <1 yr: 255.8 2007–2011 <1 yr: 163.9 −35.9
1 yr: 241.5   1 yr: 181.3 −24.9
2 yr: 133.2   2 yr: 118.3 −11.2
3 yr: 83.4   3 yr: 76.5 −8.3
Fernandes 2014 [48] Brazil, São Paulo State RV1 Hospitalisation rates/100 000 children 2000–2005 <1 yr: 1 009.3 2008–2011 <1 yr: 504.5 −50
1 yr: 743.1   1 yr: 442.5 −40
2–4 yr: 385.4   2–4 yr: 279.7 −27
All: 630.8   All: 376.6 −40
Yen 2011 [55] El Salvador RV1 Hospitalisation rates/100 000 children 2005–2006 <1 yr: 499 2008 <1 yr: 79 −84
1–2 yr: 447   1–2 yr: 63 −86
2–3 yr: 123   2–3 yr: 43 −65
3–4 yr: 30   3–4 yr: 18 −41
4–5 yr: 26   4–5 yr: 8 −68
All: 225   All: 42 −81
Yen 2011 [55] El Salvador RV1 Hospitalisation rates/100 000 children 2005–2006 <1 yr: 499 2009 <1 yr: 106 −79
1–2 yr: 447   1–2 yr: 96 −79
2–3 yr: 123   2–3 yr: 67 −46
4–5 yr: 26   4–5 yr: 23 −11
All: 225   All: 70 −69
Quintanar-Solares 2011 [52] Mexico RV1 Number of hospitalisation 2003–2006 <1 yr: 5 133 2009 <1 yr: 6 597 −40
1–2 yr: 3 944   1–2 yr: 2 441 −52
2–5 yr: 1 853   2–5 yr: 2 265 −43
Esparza-Aguilar 2014 [51] Mexico RV1 Hospitalisation rates/10 000 children 2003–2006 <1 yr: 684 2008–2011 <1 yr: 358 −48
1–2 yr: 2 301   1–2 yr: 1 195 −48
2–5 yr: 888   2–5 yr: 733 −18
All: 945   All: 590 −38
Molto 2011 [54] Panama RV1 Number of hospitalisation 2000–2005 <1 yr: 1 359 2008 <1 yr: 941 −31
1–4 yr: 2 698   1–4 yr: 1 614 −40
All: 4 057   All: 2 555 −37
Bayard 2012 [53] Panama RV1 Number of hospitalisation 2000–2005 <1 yr: 1 062 2008 <1 yr: 762 −28
1–4 yr: 1 942   1–4 yr: 1 347 −31
All: 3 004   All: 2 109 −30