Table 2 Novel antimalarial candidates in preclinical stage
From: Alternatives to currently used antimalarial drugs: in search of a magic bullet
References | Molecules | Class | Mechanism of action |
|---|---|---|---|
[66] | P218 | PfDHFR (Diaminooyridine) | Dihydrofolate reductase inhibitor |
[67] | DSM265 | Triazolopymrimidine | Dihydroorotate dehydrogenase |
[68] | Decoquinate | PfCYTbc1 | Cytochromebc1 |
[69] | KAF156 | PfCARL | Cyclic amine resistance locus protein |
[21] | 21A092 | Pyrazole | Unknown |
[70] | ELQ-300 | Quinolone-3-diarylether | Cytochrome bc1 |
[71] | RKA182 | 1,2,4,5-tetraoxane | Hemoglobin digestion |
[72] | BCX4945 | Immucillin G | Purine nucleoside phosphorylation |
[73] | NPC-1161B | 8-aminoquinoline | Unknown |
[74] | SB939 | PfHDAC1 | Histone deacetylase |
[75] | Falcitidin | PfFP2-3 | Falcipain cysteine protease 2-3 |
[76] | GSK932121 | PfCYTbc1 | Cytochromebc1 |
[28] | SJ557733 | PfATP4 | Na + −ATPase 4 |
[77] | Trichostatin A | PfHDAC1 | Histone deacetylation |
[78] | TCMDC-134674 | PfCHT1,2,4 | Aspertic protease plasmepsins 1,2,4 |
[79] | E6446 | TLR-9 | Proinflammatory cytokines antagonist |
[80] | MK4815 | Aminoindoles | Mitochondrial electron transport chain inhibitor |
[81] | Genz668764 | Carboxamide | DHOD inhibition |
[82] | RKA 182 | 1,2,4,5-tetraoxane | Hemoglobin digestion |