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Table 4 Sensitivity, specificity, predictive value, and OR of hematological parameters for differentiating between dengue and malaria

From: Differentiating between dengue fever and malaria using hematological parameters in endemic areas of Thailand

Variable Sensitivity*
(95%CI)
Specificity*
(95%CI)
PPV*
(95%CI)
NPV*
(95%CI)
P-value** OR
(95%CI)
PLR NLR
WBCs < 4 000/μL 52.5 (47.1–57.8) 87.2 (83.2–90.6) 80.9 (75.1–85.8) 64 (59.4–68.4) <0.0001 7.52 (5.12–11.03) 4.10 (3.10–5.50) 0.55 (0.48–0.61)
Neutrophils < 2 800/μL 66 (75.1–83.9) 79.8 (75.1–83.9) 77.1 (71.9–81.8) 69.4 (64.6–74.0) <0.0001 7.65 (5.41–10.82) 3.26 (2.6–4.1) 0.43 (0.36–0.5)
Lymphocytes < 800/μL 33.7 (28.8–39.0) 65.2 (59.8–70.3) 50.8 (47.0–54.6) 48.8 (44.1–53.5) 0.761 0.95 (0.69–1.31) 0.97 (0.79–1.19) 1.02 (0.91–1.13)
Monocytes < 80/μL 15.3 (11.7–19.5) 85.1 (80.9–88.8) 51.5 (41.4–61.4) 49.3 (45.2–53.5) 0.89 1.03 (0.68–1.57) 1.03 (0.72–1.47) 1 (0.93–1.06)
Eosinophils < 40/μL 33.7 (28.8–39.0) 93.8 (90.6–96.1) 84.8 (77.7–90.3) 57.8 (53.5–62.0) <0.0001 7.63 (4.65–12.51) 5.39 (3.48–8.37) 0.71 (0.65–0.77)
Basophils < 16/μL 12.7 (9.37–16.7) 80.4 (75.7–84.5) 40.0 (30.8–49.8) 47.1 (43.0–51.3) 0.013 0.594 (0.39–0.90) 0.65 (0.45–0.92) 1.09 (1.02–1.16)
NL ratio < 2.8 71.5 (66.4–76.2) 64.9 (59.5–70.0) 67.8 (62.7–72.5) 68.8 (63.4–73.8) <0.0001 4.63 (3.35–6.39) 2.04 (1.73–2.39) 0.44 (0.37–0.53)
ML ratio < 0.25 72.3 (67.3–77.0) 53.6 (48.1–59.0) 61.7 (56.8–66.4) 65.2 (59.3–70.8) <0.0001 1.77 (1.48–2.12) 1.56 (1.37–1.78) 0.52 (0.42–0.63)
RBC < 4 × 106/μL 6.34 (4.02–9.44) 87.6 (84.2–90.6) 29.0 (19.1–40.5) 54.0 (50.3–57.8) <0.0001 0.3 (0.21–59) 0.51 (0.32–0.82) 1.07 (1.02–1.12)
Hb < 11 g/dL 7.49 (4.95–10.8) 74.1 (69.1–78.7) 23.0 (15.6–31.9) 43.7 (39.6–47.9) <0.0001 0.23 (0.15–0.37) 0.29 (0.19–0.44) 1.25 (1.16–1.34)
Hct > 40% 45.8 (40.5–51.2) 81.9 (77.3–85.8) 72.3 (65.9–78.1) 59.4 (54.8–63.9) <0.0001 3.81 (2.69–5.41) 2.52 (1.96–3.25) 0.66 (0.59–0.74)
MCV > 80 fL 58.2 (52.8–63.5) 59.5 (54.1–64.8) 59.8 (54.3–65.0) 58.0 (52.6–63.2) <0.0001 2.05 (1.51–2.78) 1.44 (1.23–1.68) 0.70 (0.60–0.82)
MCH > 25 pg/cell 78.1 (73.4–82.3) 26.2 (21.6–31.2) 52.2 (47.8–56.6) 53.7 (45.7–61.5) 0.19 1.27 (0.89–1.79) 1.06 (0.97–1.15) 0.84 (0.64–1.09)
MCHC > 33 g/dL 52.7 (47.3–58.1) 53.0 (47.5–58.4) 53.7 (48.2–59.1) 52.1 (46.6–57.5) 0.135 1.26 (0.93–1.70) 1.12 (0.96–1.13) 0.89 (0.77–1.04)
RDW > 13% 25.4 (20.9–30.3) 71.7 (66.6–76.5) 48.1 (40.7–55.6) 48.2 (43.7–52.7) 0.390 0.86 (0.61–1.21) 0.9 (0.70–1.15) 1.04 (0.95–1.14)
Platelets +< 100 000/μL 73.8 (68.8–78.3) 33.6 (28.6–39.0) 53.4 (48.9–58.0) 55.4 (48.3–62.3) 0.034 1.43 (1.23–1.98) 1.11 (1.01–1.23) 0.78 (0.62–0.98)
  1. PLR positive likelihood ratio, NLR negative likelihood ratio
  2. *Percent, **P-value determined using the chi-square test