Table 4 Sensitivity, specificity, predictive value, and OR of hematological parameters for differentiating between dengue and malaria

WBCs < 4 000/μL

52.5 (47.1–57.8)

87.2 (83.2–90.6)

80.9 (75.1–85.8)

64 (59.4–68.4)

<0.0001

7.52 (5.12–11.03)

4.10 (3.10–5.50)

0.55 (0.48–0.61)

Neutrophils < 2 800/μL

66 (75.1–83.9)

79.8 (75.1–83.9)

77.1 (71.9–81.8)

69.4 (64.6–74.0)

<0.0001

7.65 (5.41–10.82)

3.26 (2.6–4.1)

0.43 (0.36–0.5)

Lymphocytes < 800/μL

33.7 (28.8–39.0)

65.2 (59.8–70.3)

50.8 (47.0–54.6)

48.8 (44.1–53.5)

0.761

0.95 (0.69–1.31)

0.97 (0.79–1.19)

1.02 (0.91–1.13)

Monocytes < 80/μL

15.3 (11.7–19.5)

85.1 (80.9–88.8)

51.5 (41.4–61.4)

49.3 (45.2–53.5)

0.89

1.03 (0.68–1.57)

1.03 (0.72–1.47)

1 (0.93–1.06)

Eosinophils < 40/μL

33.7 (28.8–39.0)

93.8 (90.6–96.1)

84.8 (77.7–90.3)

57.8 (53.5–62.0)

<0.0001

7.63 (4.65–12.51)

5.39 (3.48–8.37)

0.71 (0.65–0.77)

Basophils < 16/μL

12.7 (9.37–16.7)

80.4 (75.7–84.5)

40.0 (30.8–49.8)

47.1 (43.0–51.3)

0.013

0.594 (0.39–0.90)

0.65 (0.45–0.92)

1.09 (1.02–1.16)

NL ratio < 2.8

71.5 (66.4–76.2)

64.9 (59.5–70.0)

67.8 (62.7–72.5)

68.8 (63.4–73.8)

<0.0001

4.63 (3.35–6.39)

2.04 (1.73–2.39)

0.44 (0.37–0.53)

ML ratio < 0.25

72.3 (67.3–77.0)

53.6 (48.1–59.0)

61.7 (56.8–66.4)

65.2 (59.3–70.8)

<0.0001

1.77 (1.48–2.12)

1.56 (1.37–1.78)

0.52 (0.42–0.63)

RBC < 4 × 10⁶/μL

6.34 (4.02–9.44)

87.6 (84.2–90.6)

29.0 (19.1–40.5)

54.0 (50.3–57.8)

<0.0001

0.3 (0.21–59)

0.51 (0.32–0.82)

1.07 (1.02–1.12)

Hb < 11 g/dL

7.49 (4.95–10.8)

74.1 (69.1–78.7)

23.0 (15.6–31.9)

43.7 (39.6–47.9)

<0.0001

0.23 (0.15–0.37)

0.29 (0.19–0.44)

1.25 (1.16–1.34)

Hct > 40%

45.8 (40.5–51.2)

81.9 (77.3–85.8)

72.3 (65.9–78.1)

59.4 (54.8–63.9)

<0.0001

3.81 (2.69–5.41)

2.52 (1.96–3.25)

0.66 (0.59–0.74)

MCV > 80 fL

58.2 (52.8–63.5)

59.5 (54.1–64.8)

59.8 (54.3–65.0)

58.0 (52.6–63.2)

<0.0001

2.05 (1.51–2.78)

1.44 (1.23–1.68)

0.70 (0.60–0.82)

MCH > 25 pg/cell

78.1 (73.4–82.3)

26.2 (21.6–31.2)

52.2 (47.8–56.6)

53.7 (45.7–61.5)

0.19

1.27 (0.89–1.79)

1.06 (0.97–1.15)

0.84 (0.64–1.09)

MCHC > 33 g/dL

52.7 (47.3–58.1)

53.0 (47.5–58.4)

53.7 (48.2–59.1)

52.1 (46.6–57.5)

0.135

1.26 (0.93–1.70)

1.12 (0.96–1.13)

0.89 (0.77–1.04)

RDW > 13%

25.4 (20.9–30.3)

71.7 (66.6–76.5)

48.1 (40.7–55.6)

48.2 (43.7–52.7)

0.390

0.86 (0.61–1.21)

0.9 (0.70–1.15)

1.04 (0.95–1.14)

Platelets +< 100 000/μL

73.8 (68.8–78.3)

33.6 (28.6–39.0)

53.4 (48.9–58.0)

55.4 (48.3–62.3)

0.034

1.43 (1.23–1.98)

1.11 (1.01–1.23)

0.78 (0.62–0.98)