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Table 1 Activity observed with drug discovery candidates in the S. mansoni-mouse model

From: Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?

Chemical compound/drug Dose Worm burden reduction (adult) Worm burden reduction (juvenile) Reference
Artemether 300 mg/kg/day for 2 days 85.4–98.3% 70% [52]
Artesunate 150 or 300 mg/kg/day for 7 days 34–49% 67–77% [53]
Bisquinoline cyclen derivative 400 mg/kg single dose 12.3% Not done [74]
Bisquinoline cyclen derivative (Fe++ complex) 400 mg/kg single dose 88.4% Not done [74]
Bisquinoline cyclen derivative (Mn++ complex) 400 mg/kg single dose 74.5% Not done [74]
Chlorambucil 2.5 mg/kg/day for 5 days 22.7% 75.8% [77]
Clofazimine 400 mg/kg single dose 82.7% Not done [84]
2,3-dianilinoquinoxaline MMV007224 400 mg/kg single dose 40.8% Not done [71]
N,N’-Diarylurea MMV665852 400 mg/kg single dose 52.5% Not done [71]
N,N’-Diarylurea MMV665852 analogs 400 mg/kg single dose 9.3–36% Not done [72]
Doramectin 10 mg/kg single dose 60.1% Not done [84]
Mefloquine 400 mg/kg single dose (adult), 100 mg/kg (juvenile) 77.3% 94.2% [65]
Mefloquine derivatives 100 mg/kg single dose 0-87% Not done [69]
Miltefosin 20 mg/kg daily for 5 days 95.4% 75.5% [75]
OZ78 200 mg/kg single dose (juvenile), 400 mg/kg single dose (adult) 0% 82% [57]
OZ209 200 mg/kg single dose (juvenile), 400 mg/kg single dose (adult) 16% 85% [57]
OZ288 200 mg/kg single dose (juvenile), 400 mg/kg single dose (adult) 52.2% 95.4% [57]
OZ418 200 mg/kg single dose (juvenile), 400 mg/kg single dose (adult) 80% 100% [59]
Perhexiline maleate 23, 70 and 400 mg/kg single dose Not given Not given [83]
Piperaquine/OZ277 (Synriam) 40 mg/kg arterolane (OZ277) and 200 mg/kg piperaquine 88.7% 85.4% [61]
Ferroquine 200 mg/kg and 800 mg/kg single dose 19.4% and 35.6% Not done [73]