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Table 2 Summary of four recent clinical trials with drugs repositioned for use against chronic infections with S. mansoni and S. haematobium

From: Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?

Compound S. mansoni S. haematobium Reference
Cure rate
(%)
Egg reduction rate
(%)
Cure rate
(%)
Egg reduction rate
(%)
Artesunate Not done Not done 25 85 [104]
Mefloquine Not done Not done 21 74 [104]
Mefloquine-artesunate Not done Not done 61 96 [104]
Mefloquine-artesunate-praziquantel Not done Not done 29 96 [105]
Moxidectin 13 71 15 9 [103]
Synriam 7 65 11 0 [103]
Praziquantel-Synriam 27 78 60 96 [103]
ARA Arachidonic acid 13–50 0–64 Not done Not done [109]