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Table 2 Summary of four recent clinical trials with drugs repositioned for use against chronic infections with S. mansoni and S. haematobium

From: Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?

Compound

S. mansoni

S. haematobium

Reference

Cure rate

(%)

Egg reduction rate

(%)

Cure rate

(%)

Egg reduction rate

(%)

Artesunate

Not done

Not done

25

85

[104]

Mefloquine

Not done

Not done

21

74

[104]

Mefloquine-artesunate

Not done

Not done

61

96

[104]

Mefloquine-artesunate-praziquantel

Not done

Not done

29

96

[105]

Moxidectin

13

71

15

9

[103]

Synriam

7

65

11

0

[103]

Praziquantel-Synriam

27

78

60

96

[103]

ARA Arachidonic acid

13–50

0–64

Not done

Not done

[109]