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Table 6 Comparison of key amino acid residues of the E protein related to neurovirulence of JEVa

From: Pigsties near dwellings as a potential risk factor for the prevalence of Japanese encephalitis virus in adult in Shanxi, China

Strain E107 E138 E176 E177 E264 E279 E315 E439
SA-14-14-2 (GIII) Phe(F) Lys(K) Val(V) Ala(A) His(H) Met(M) Val(V) Arg(R)
SXYC1523b(GI) Leu(L) Glu(E) Ile(I) Thr(T) Gln(Q) Lys(K) Ala(A) Lys(K)
SXYC1546b(GI) Leu(L) Glu(E) Ile(I) Thr(T) Gln(Q) Lys(K) Ala(A) Lys(K)
SXYC1548b(GI) Leu(L) Glu(E) Ile(I) Thr(T) Gln(Q) Lys(K) Ala(A) Lys(K)
SX09S-01(GI) Leu(L) Glu(E) Ile(I) Thr(T) Gln(Q) Lys(K) Ala(A) Lys(K)
12-YJ033(GI) Leu(L) Glu(E) Ile(I) Thr(T) Gln(Q) Lys(K) Ala(A) Lys(K)
GZ56(GI) Leu(L) Glu(E) Ile(I) Thr(T) Gln(Q) Lys(K) Ala(A) Lys(K)
FU(GII) Leu(L) Glu(E) Ile(I) Thr(T) Gln(Q) Lys(K) Ala(A) Lys(K)
Nakayama(GIII) Leu(L) Glu(E) Ile(I) Thr(T) Gln(Q) Lys(K) Ala(A) Lys(K)
P3 (GIII) Leu(L) Glu(E) Ile(I) Thr(T) Gln(Q) Lys(K) Ala(A) Lys(K)
JKT6468(GIV) Leu(L) Glu(E) Ile(I) Thr(T) Gln(Q) Lys(K) Ala(A) Lys(K)
Muar(GV) Leu(L) Glu(E) Ile(I) Thr(T) Gln(Q) Lys(K) Ala(A) Lys(K)
XZ0934(GV) Leu(L) Glu(E) Ile(I) Thr(T) Gln(Q) Lys(K) Ala(A) Lys(K)
  1. aThese eight aa residues of the E protein were shown to play a key role in neurovirulence. They are very different between the attenuated vaccine strain (SA14-14-2) and the virulent strains
  2. bIsolated in Shanxi, 2015 in this study