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Table 4 Multinomial analysis of the association between antibody response pattern, serotype and severity of dengue disease as outcome

From: Dengue-specific serotype related to clinical severity during the 2012/2013 epidemic in centre of Brazil

Parameters Dengue Fever Dengue with Warning Signs Severe Dengue
N = 188 (%) N = 238 (%) OR (95% CI) P-value N = 26 (%) OR (95% CI) P-value
Gender
 Female 78 (41.5) 143 (60.1) 2.12 (1.44–3.13) 0.000 14 (53.8) 1.64 (0.72–3.75) 0.236
Age group (years)
  < 15 12 (6.4) 27 (11.3) Reference 3 (11.5) Reference
  ≥ 15 176 (93.6) 211 (88.7) 0.53 (0.26–1.08) 0.082 23 (88.5) 0.52 (0.14–1.99) 0.342
Comorbidity 46 (24.5) 60 (25.2) 1.04 (0.67–1.62) 0.860 9 (34.6) 1.63 (0.68–3.92) 0.271
Antibody response patterna
 Primary 53 (28.2) 62 (26.1) Reference 3 (11.5) Reference
 Secondary 121 (64.4) 146 (61.3) 1.03 (0.66–1.60) 0.890 18 (69.2) 2.63 (0.74–9.30) 0.134
Serotypeb
 DENV-1 35 (19.7) 47 (19.7) Reference 9 (34.6) NA
 DENV-4 63 (35.4) 72 (30.3) 0.85 (0.49–1.48) 0.568 0 NA
  1. Reference for the multinomial analysis: dengue fever
  2. NA Not applicable
  3. a49 patients not evaluated
  4. bSerotypes determined by reverse-transcription polymerase chain reaction (RT-PCR) and 226 patients not evaluated