Molecular markers for artemisinin and partner drug resistance in natural Plasmodium falciparum populations following increased insecticide treated net coverage along the slope of mount Cameroon: cross-sectional study

Table 2 Most prevalent drug resistant mutations in P. falciparum isolates from the slope of mount Cameroon

Gene	Codons	This study Prevalence (isolates)	Previous reports in area^α or elsewhere in Cameroon^β
Gene	Codons	This study Prevalence (isolates)	Prevalence (isolates)	Year of sampling	Reference
Pfcrt	M74I	55.0 (116)	NR	NR	NR
	N75E	54.2 (115)	NR	NR	NR
	K76 T(R,I)	55.2 (116)	87.1	2004–2006	Mbacham et al., 2010^α [44]
	Q271K	62.5 (120)	NR	NR	NR
	I356K	46.1 (77)	NR	NR	NR
Pfdhfr	N51I	99.6 (232)	96.1 (51)	2010–2011	Chauvin et al., 2015^β [63]
	C59R	99.6 (232)	98 (51)
	S108 N	100 (233)	98 (51)
Pfdhps	K142 N	9.2 (19)	NR	NR	NR
	I431V	17.6 (31)	9.8 (51)	2010–2011	Chauvin et al., 2015^β [63]
	S436A	32.0 (39)	47.1 (51)
	A581G	9.8 (19)	5.9 (51)
	A613S	12.3 (18)	11.8 (51)
Pfmdr1	N86Y	13.0 (25)	73.8	2004–2006	Mbacham et al., 2010^α [44]
Pfmdr1	Y184F	72.0 (121)	9 (64)	1997–2000	Basco et al., 2002^β [41]
Pfkelch13	K189 T	36.0 (58)	NR	NR	NR

α and β denote reports from the study area and elsewhere in Cameroon respectively; NR = No Reports

ISSN: 2049-9957