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Table 3 Prevalence of point mutation haplotype in the P. falciparum CQ resistance transporter, dihydrofolate reductase, dihydropteroate synthetase, and multidrug resistance 1 genotypes among clinical samples from different localities in south western Cameroon

From: Molecular markers for artemisinin and partner drug resistance in natural Plasmodium falciparum populations following increased insecticide treated net coverage along the slope of mount Cameroon: cross-sectional study

Drug implicated Gene (codons) Haplotype (amino acids) Prevalence [n (%)] Area (%) P-value
MT MM CB  
CQ, AQ, LM pfcrt (72–76) CVIET 112 (47.3) 51.7 46.6 47.3 0.905
CVMNK 60 (25.3) 27.6 23.6 25.5
CVIET + CVMNK 65 (27.4) 20.7 29.7 27.3
SP pfdhfr (51, 59, 108, 164) IRNI 232 (99.6) 100 99.3 100 0.754
NCNI 1 (0.4) 0.0 0.7 0.0
pfdhps (436, 437, 540, 581, 613) SGKAA 67 (69.1) 66.7 65.1 75.0 0.925
AGKAA 10 (10.3) 22.2 7.9 15.0
AGKGS 10 (10.3) 11.1 12.7 5.0
AAKAA 5 (5.2) 0.0 6.3 5.0
AGKAS 3 (3.1) 0.0 4.8 0.0
AAKGS 1 (1.0) 0.0 1.6 0.0
SAKAA 1 (1.0) 0.0 1.6 3.0
AQ, CQ, LM, MQ pfmdr-1 (86, 184, 1246) NFD 74 (53.2) 71.4 55.7 40.0 0.169
NYD 46 (33.1) 7.1 30.7 48.6
YFD 18 (12.9) 21.4 12.5 11.4
YYD 1 (0.7) 0.0 1.1 0.0
  1. Boldface letters depict mutant alleles; AQ amodiaquine, CQ chloroquine, LM lumefantrine, MQ mefloquine, SP sulphadoxine–pyrimethamine, MT Mutengene & Tiko, MM Mile 14 to Muea transect, CB Checkpoint-Molyko to Buea Town transect