Table 3 Prevalence of point mutation haplotype in the P. falciparum CQ resistance transporter, dihydrofolate reductase, dihydropteroate synthetase, and multidrug resistance 1 genotypes among clinical samples from different localities in south western Cameroon
Drug implicated | Gene (codons) | Haplotype (amino acids) | Prevalence [n (%)] | Area (%) | P-value | ||
|---|---|---|---|---|---|---|---|
MT | MM | CB | Â | ||||
CQ, AQ, LM | pfcrt (72–76) | CVIET | 112 (47.3) | 51.7 | 46.6 | 47.3 | 0.905 |
CVMNK | 60 (25.3) | 27.6 | 23.6 | 25.5 | |||
CVIETÂ +Â CVMNK | 65 (27.4) | 20.7 | 29.7 | 27.3 | |||
SP | pfdhfr (51, 59, 108, 164) | IRNI | 232 (99.6) | 100 | 99.3 | 100 | 0.754 |
NCNI | 1 (0.4) | 0.0 | 0.7 | 0.0 | |||
pfdhps (436, 437, 540, 581, 613) | SGKAA | 67 (69.1) | 66.7 | 65.1 | 75.0 | 0.925 | |
AGKAA | 10 (10.3) | 22.2 | 7.9 | 15.0 | |||
AGKGS | 10 (10.3) | 11.1 | 12.7 | 5.0 | |||
AAKAA | 5 (5.2) | 0.0 | 6.3 | 5.0 | |||
AGKAS | 3 (3.1) | 0.0 | 4.8 | 0.0 | |||
AAKGS | 1 (1.0) | 0.0 | 1.6 | 0.0 | |||
SAKAA | 1 (1.0) | 0.0 | 1.6 | 3.0 | |||
AQ, CQ, LM, MQ | pfmdr-1 (86, 184, 1246) | NFD | 74 (53.2) | 71.4 | 55.7 | 40.0 | 0.169 |
NYD | 46 (33.1) | 7.1 | 30.7 | 48.6 | |||
YFD | 18 (12.9) | 21.4 | 12.5 | 11.4 | |||
YYD | 1 (0.7) | 0.0 | 1.1 | 0.0 | |||