Infectious Diseases of Poverty

Table 2 Budget impact analyses with baseline parameters

From: Health economic evaluation of moist wound care in chronic cutaneous leishmaniasis ulcers in Afghanistan

	Number of patients (N)^a
	WHO EMRO protocol	Group I	Group II	Group III
Health states
Non-Compliant	65 500	65 500	47 683	43 780
Primary closure	81 621	81 621	104 868	86 712
No primary closure	4582	4582	1358	1358
Final closure	13 575	13 575	10 521	10 860
No final closure	4582	4582	5260	27 150
	Budget impact (US$ 2013)^a
	No treatment	Group I	Group II	Group III
Health states
Non-Compliant	–	527 278	405 781	398 398
Primary closure	–	1 020 261	1 483 888	1 418 602
No primary closure	–	77 888	140 300	127 715
Final closure	–	224 127	268 069	314 727
No final closure	–	92 503	409 206	1 983 880
Total
Av. incidence (169 860 cases)	879 875	1 942 056	2 707 244	4 243 322
Min. incidence (113 100 cases)	585 858	1 294 399	1 804 404	2 828 215
Max. incidence (226 280 cases)	1 172 130	2 589 714	3 610 085	5 658 430
NMLCP rep. Incidence (22 620 cases)	117 172	258 880	360 881	565 643
	Drug cost (US$ 2013)^a
	WHO EMRO protocol	Group I	Group II	Group III
Health states
Non-Compliant	86 460	25 938	22 292	27 910
Primary closure	430 958	129 287	196 104	221 115
No primary closure	24 191	7257	23 309	23 309
Final closure	116 475	30 463	37 559	51 694
No final closure	39 310	10 281	64 387	336 936
Total
Av. incidence (169 860 cases)	697 395	203 227	343 650	660 963
Min. incidence (113 100 cases)	464 821	135 453	229 046	440 538
Max. incidence (226 280 cases)	929 970	271 001	458 254	881 388
NMLCP rep. Incidence (22 620 cases)	92 964	27 091	45 809	88 107

^a The budget impact calculations for the average estimated incidence differentiated by health states is calculated with the total average cost per patient with one lesion and the drug cost for each regimen. Drug costs represent solely the costs of SSG and DAC N-055 basic crème according to the pre-defined dosage and posology. The number of patients are based on estimated average incidence published by Alvar et al. [5] and the probability of final health states used in the present decision tree model. In case “no treatment” is administered, based on Afghan 2013 per capita income of US$ 700 and an average lesion duration of 303 days, according to our simple model and the educated guess, indirect cost due to one CL lesion amount to US$ 5.81. If additionally, productivity loss due to CL exceeds 1% of daily income, the societal budget impact of “no treatment” is considerable

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ISSN: 2049-9957

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