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Table 2 Budget impact analyses with baseline parameters

From: Health economic evaluation of moist wound care in chronic cutaneous leishmaniasis ulcers in Afghanistan

  Number of patients (N)a
  WHO EMRO protocol Group I Group II Group III
Health states
 Non-Compliant 65 500 65 500 47 683 43 780
 Primary closure 81 621 81 621 104 868 86 712
 No primary closure 4582 4582 1358 1358
 Final closure 13 575 13 575 10 521 10 860
 No final closure 4582 4582 5260 27 150
  Budget impact (US$ 2013)a
  No treatment Group I Group II Group III
Health states
 Non-Compliant 527 278 405 781 398 398
 Primary closure 1 020 261 1 483 888 1 418 602
 No primary closure 77 888 140 300 127 715
 Final closure 224 127 268 069 314 727
 No final closure 92 503 409 206 1 983 880
Total
 Av. incidence (169 860 cases) 879 875 1 942 056 2 707 244 4 243 322
 Min. incidence (113 100 cases) 585 858 1 294 399 1 804 404 2 828 215
 Max. incidence (226 280 cases) 1 172 130 2 589 714 3 610 085 5 658 430
 NMLCP rep. Incidence (22 620 cases) 117 172 258 880 360 881 565 643
  Drug cost (US$ 2013)a
  WHO EMRO protocol Group I Group II Group III
Health states
 Non-Compliant 86 460 25 938 22 292 27 910
 Primary closure 430 958 129 287 196 104 221 115
 No primary closure 24 191 7257 23 309 23 309
 Final closure 116 475 30 463 37 559 51 694
 No final closure 39 310 10 281 64 387 336 936
Total
 Av. incidence (169 860 cases) 697 395 203 227 343 650 660 963
 Min. incidence (113 100 cases) 464 821 135 453 229 046 440 538
 Max. incidence (226 280 cases) 929 970 271 001 458 254 881 388
 NMLCP rep. Incidence (22 620 cases) 92 964 27 091 45 809 88 107
  1. a The budget impact calculations for the average estimated incidence differentiated by health states is calculated with the total average cost per patient with one lesion and the drug cost for each regimen. Drug costs represent solely the costs of SSG and DAC N-055 basic crème according to the pre-defined dosage and posology. The number of patients are based on estimated average incidence published by Alvar et al. [5] and the probability of final health states used in the present decision tree model. In case “no treatment” is administered, based on Afghan 2013 per capita income of US$ 700 and an average lesion duration of 303 days, according to our simple model and the educated guess, indirect cost due to one CL lesion amount to US$ 5.81. If additionally, productivity loss due to CL exceeds 1% of daily income, the societal budget impact of “no treatment” is considerable