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Table 1 The minimal effective concentrations (MECs) of praziquantel needed to induce an increased in motor activity, contraction of musculature or vesicle formation in different developmental stages of S. mansoni and S. japonicum

From: Pharmacological and immunological effects of praziquantel against Schistosoma japonicum: a scoping review of experimental studies

Stage MEC (μg/ml) producing Time of onset of vesiculation Vesicle numberb
Stimulation Contraction Vesiculationa
S. mansoni Reference [26]
 Day 0 0.005 0.010 0.1 2–4 h Few
 Day 3 0.010 0.010 1.0 >  4 h Few
 Day 7 0.010 0.010 1.0 >  4 h Few
 Day 14 0.010 0.010 0.1 30 min Many
 Day 28 0.005 0.010 0.1 30 min Many
 Day 35 0.005 0.010 0.1 5–15 min Very many
 Day 42 0.005 0.010 0.1 5–15 min Very many
S. japonicum Reference [41]
 Day 0 0.01 0.05 0.5 3–4 h Few
 Day 3 0.01 0.05 1.0 24 h Very few
 Day 7 0.01 0.05 1.0 24 h Very few
 Day 14 0.01 0.05 1.0 2 h Many
 Day 21 0.01 0.05 0.1 2 h Many
 Day 28 0.005 0.05 0.1 2 h Many
 Day 35 0.005 0.05 0.1 15 min Very many
 Day 42 0.005 0.05 0.1 15 min Very many
  1. aObserved by light microscopy
  2. bFew ≤ 5 vesicle per parasite, many = 5–20 vesicles per parasite, and very many ≥20 vesicles per parasite