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Table 2 Praziquantel-induced damage on tegument in different developmental stages of S. japonicum, harbouring in mice, and treated orally with the drug at a single dose of 400 mg/kg for 0.5–24 hoursa

From: Pharmacological and immunological effects of praziquantel against Schistosoma japonicum: a scoping review of experimental studies

Developmental stages of schistosomes (d) Percentages of worm tegument showing damageb Host cell response expressed by dominant leukocytesc
Vesiculation Rupture Neutrophils Lymphocytes
d0 41.8 49.2 47.5 ± 8.2  
d21, d28, d35, d42 20.4–38.7 17.9–56.2 26.8 ± 5.2–58.4 ± 12.2d  
d3, d11, d14 Normal tegument in most worms, or emergence of very few vesicles   12.8 ± 5.9–16.8 ± 5.0
d7 Ditto   2.5 ± 0.7
  1. aData from reference [44]
  2. b2–3 mice harbouring different developmental stages of schistosomes killed 0.5, 1, 4 and 24 hr after treatment, skins (d0), lungs (d3) or livers (d11, d14, d21, d28, d35, d42) removed for routine preparation of tissue section
  3. cEach value represents 40–80 sections
  4. dThe cells around the d21 schistosomules mainly lymphocytes