Skip to main content

Table 3 Pharmacokinetics and therapeutic efficacy of praziquantel in S. japonicum-infected mice and rabbits after oral (PO), rectal (PR) and intramuscular (IM) administration

From: Pharmacological and immunological effects of praziquantel against Schistosoma japonicum: a scoping review of experimental studies

Animal Time after infection (week) Dose (mg/kg) Route Tmax (h) Cmax (μg/ml) T1/2 (h) AUC0-∞ (μg/ml × h) Worm burden reduction (%) Reference
Mice 4 300 PO 0.27 20.2 0.8 30.6 46.2  
5 300 PO 0.59 29.1 0.5 49.8 65.3  
5 150 IM 0.58 31.3 0.7 60.3 52.2  
6 300 PO 0.50 34.0 0.6 55.2 93.8  
Rabbits 4 40 PO 0.3 0.05 0.9 0.08 60.8  
8 40 PO 0.34 0.64 3.04 3.03 94.9  
12 40 PO 0.43 0.50 1.08 1.01 89.0  
4 20 IM 1.49 1.92 1.27 8.17 70.9  
8 20 IM 1.32 1.65 1.86 7.59 88.0  
12 20 IM 1.11 1.45 1.35 5.25 95.2 [83]
8 40 PO 0.5–0.6 0.1–0.3 1.3–1.6 0.1–0.9 72.5  
8 40 PR 0.4 0.7–0.8 0.5–0.6 0.9–1.0 90.1  
8 20 IM 0.5–1.2 0.8–2.3 1.2–1.6 2.6–5.9 92.2 [84]