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Table 4 Comparison of clinical characteristics between BALF bacteriologically negative and positive patients within sputum negative pulmonary TB patients and those without sputum

From: Indicators for prediction of Mycobacterium tuberculosis positivity detected with bronchoalveolar lavage fluid

  Total BALF (+) BALF (−) P-value OR (95% CI)
N = 1028 n = 285 n = 743
Age 37.4 ± 14.2 32.7 ± 12.8 39.3 ± 14.2 <  0.001  
Male 589 154 (26.1%) 435 (73.9%) 0.191 0.832 (0.632~ 1.096)
TB history 126 40 (31.7%) 86 (68.3%) 0.282 1.247 (0.834–1.866)
Fever 363 94 (25.9%) 269(74.1%) 0.333 0.867 (0.650–1.157)
Night sweat 97 28 (28.9%) 69 (71.1%) 0.792 1.064 (0.670–1.689)
Cough 751 213 (28.4%) 538 (71.6%) 0.451 1.127 (0.825–1.540)
Hemoptysis 158 60 (38.0%) 98 (62.0%) 0.002 1.755 (1.230–2.504)
Lose weight 222 72 (32.4%) 150 (67.6%) 0.077 1.336 (0.969–1.843)
Bilateral lung 268 92 (34.3%) 176 (65.7%) 0.005 1.536 (1.137–2.074)
Cavity 104 57 (54.8%) 47 (45.2%) <  0.001 4.108 (2.376–7.102)
aCD4 595.8 ± 274.4 547.77 ± 246.14 615.8 ± 283.2 0.004  
aCD4≤500 264 92 (34.8%) 172 (65.2%) 0.011 1.540 (1.101–2.153)
aCD8 420.0 ± 205.4 380.30 ± 181.83 436.7 ± 212.6 0.001  
aCD8≤500 468 153 (32.7%) 315 (67.3%) 0.002 1.992 (1.289–3.076)
ESR 40.9 ± 31.3 46.08 ± 29.97 39.0 ± 31.6 0.001  
IGRA (+)b 507 201 (39.6%) 306 (60.4%) <  0.001 3.743 (2.478–5.655)
  1. BALF bronchoalveolar lavage fluid, IGRA interferon-γ release assays, ESR erythrocyte sedimentation rate
  2. aTotal N = 679, BALF (+) n = 199, BALF (−) n = 480
  3. bTotal N = 938, BALF (+) n = 270, BALF (−) n = 692