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Table 2 Risk factors associated with the mortality of HIV infected patients with PTBa

From: Risk factors affecting the mortality of HIV-infected patients with pulmonary tuberculosis in the cART era: a retrospective cohort study in China

Risk factor Univariate analysis Multivariate analysis
HRb (95% CI) P value HRb (95% CI) P value
Age > 60 3.31 (1.80–6.10) < 0.001 3.18 (1.66–6.10) 0.001
Male gender 0.97 (0.39–2.43) 0.942   
Not on cART 2.17 (1.03–4.61) 0.043 1.48 (0.67–3.25) 0.332
Diagnosis delay 3.05 (1.71–5.44) < 0.001 2.60 (1.42–4.78) 0.002
Clinical symptoms
 Fever (> 39 °C) 0.56 (0.32–0.97) 0.037 0.54 (0.30–0.96) 0.037
 Cough 1.05 (0.61–1.81) 0.850   
 Expectoration 1.58 (0.89–2.81) 0.122   
 Anorexia 1.14 (0.61–2.12) 0.690   
 Dyspnea 1.88 (1.04–3.37) 0.036 1.03 (0.53–1.97) 0.941
Extrapulmonary Involvement 1.83 (0.96–3.48) 0.066   
CD4+ T cell count < 50 cells/mm3 2.70 (1.48–4.90) 0.001 2.38 (1.27–4.43) 0.007
Comorbidities
 Bacterial pneumonia 4.07 (2.21–7.52) < 0.001 2.64 (1.30–5.35) 0.007
 HBV/HCV co-infection 1.57 (0.67–3.68) 0.298   
 Syphilis 0.18 (0.03–1.32) 0.093   
 Diabetes 0.96 (0.23–3.92) 0.949   
 Hypertension 1.13 (0.27–4.62) 0.871   
Manifestation of lung CT scan
 Extensive pulmonary lesion 2.39 (1.26–4.55) 0.008 1.76 (0.90–3.44) 0.100
 Pulmonary cavity 2.00 (0.98–4.10) 0.058   
 Pulmonary atelectasis 2.29 (1.12–4.70) 0.023 2.20 (1.05–4.60) 0.037
  1. aStatistical analysis was performed by the Cox proportional-hazards model
  2. bHR indicated relative mortality risk for cases with the specific risk factor referred to cases without the corresponding risk factor