Risk factors affecting the mortality of HIV-infected patients with pulmonary tuberculosis in the cART era: a retrospective cohort study in China

Table 2 Risk factors associated with the mortality of HIV infected patients with PTB^a

Risk factor	Univariate analysis		Multivariate analysis
Risk factor	HR^b (95% CI)	P value	HR^b (95% CI)	P value
Age > 60	3.31 (1.80–6.10)	< 0.001	3.18 (1.66–6.10)	0.001
Male gender	0.97 (0.39–2.43)	0.942
Not on cART	2.17 (1.03–4.61)	0.043	1.48 (0.67–3.25)	0.332
Diagnosis delay	3.05 (1.71–5.44)	< 0.001	2.60 (1.42–4.78)	0.002
Clinical symptoms
Fever (> 39 °C)	0.56 (0.32–0.97)	0.037	0.54 (0.30–0.96)	0.037
Cough	1.05 (0.61–1.81)	0.850
Expectoration	1.58 (0.89–2.81)	0.122
Anorexia	1.14 (0.61–2.12)	0.690
Dyspnea	1.88 (1.04–3.37)	0.036	1.03 (0.53–1.97)	0.941
Extrapulmonary Involvement	1.83 (0.96–3.48)	0.066
CD4⁺ T cell count < 50 cells/mm³	2.70 (1.48–4.90)	0.001	2.38 (1.27–4.43)	0.007
Comorbidities
Bacterial pneumonia	4.07 (2.21–7.52)	< 0.001	2.64 (1.30–5.35)	0.007
HBV/HCV co-infection	1.57 (0.67–3.68)	0.298
Syphilis	0.18 (0.03–1.32)	0.093
Diabetes	0.96 (0.23–3.92)	0.949
Hypertension	1.13 (0.27–4.62)	0.871
Manifestation of lung CT scan
Extensive pulmonary lesion	2.39 (1.26–4.55)	0.008	1.76 (0.90–3.44)	0.100
Pulmonary cavity	2.00 (0.98–4.10)	0.058
Pulmonary atelectasis	2.29 (1.12–4.70)	0.023	2.20 (1.05–4.60)	0.037

^aStatistical analysis was performed by the Cox proportional-hazards model
^bHR indicated relative mortality risk for cases with the specific risk factor referred to cases without the corresponding risk factor

ISSN: 2049-9957