Table 2 Frequency (f) and number (n) of antibody responders (R) and non-responders (NR) to CS peptide repeats for P. vivax, P. falciparum, and P. malariae according to HLA-DRB1 and HLA-DQB1 genotypes
PvCS | PfCS | PmCS | ||||
|---|---|---|---|---|---|---|
R | NR | R | NR | R | NR | |
f (n) | f (n) | f (n) | f (n) | f (n) | f (n) | |
HLA-DRB1 | ||||||
DRB1*01 | 0.05 (18) | 0.15 (30) *** | 0.04 (12) | 0.13 (36) *** | 0.06 (15) | 0.11 (33) |
DRB1*03 | 0.06 (23) | 0.05 (9) | 0.06 (17) | 0.05 (15) | 0.06 (16) | 0.05 (16) |
DRB1*04 | 0.16 (59) | 0.15 (29) | 0.18 (52) | 0.13 (36) | 0.14 (35) | 0.17 (53) |
DRB1*07 | 0.12 (43) | 0.08 (16) | 0.13 (36) | 0.08 (23) | 0.11 (27) | 0.10 (32) |
DRB1*08 | 0.07 (27) | 0.10 (19) | 0.09 (25) | 0.08 (21) | 0.09 (23) | 0.07 (23) |
DRB1*09 | 0.02 (9) | 0.03 (6) | 0.02 (6) | 0.03 (9) | 0.02 (6) | 0.03 (9) |
DRB1*10 | 0.03 (12) | 0.02 (3) | 0.01 (4) | 0.04 (11) | 0.03 (7) | 0.03 (8) |
DRB1*11 | 0.11 (40) | 0.10 (19) | 0.10 (27) | 0.12 (32) | 0.12 (31) | 0.09 (28) |
DRB1*12 | 0.01 (2) | 0.03 (5) | 0.01 (3) | 0.01 (4) | 0.01 (3) | 0.01 (4) |
DRB1*13 | 0.15 (56) | 0.11 (22) | 0.15 (41) | 0.13 (37) | 0.14 (34) | 0.14 (44) |
DRB1*14 | 0.04 (16) | 0.04 (7) | 0.05 (13) | 0.04 (10) | 0.04 (9) | 0.05 (14) |
DRB1*15 | 0.09 (33) | 0.10 (19) | 0.08 (23) | 0.10 (29) | 0.10 (26) | 0.08 (26) |
DRB1*16 | 0.08 (28) | 0.05 (10) | 0.08 (23) | 0.05 (15) | 0.07 (18) | 0.06 (20) |
HLA-DQB1 | ||||||
DQB1*02 | 0.17 (62) | 0.12 (24) | 0.19 (53)* | 0.12 (33) | 0.17 (43) | 0.14 (43) |
DQB1*03 | 0.40 (145) | 0.34 (65) | 0.41 (116) | 0.34 (94) | 0.38 (96) | 0.37 (114) |
DQB1*04 | 0.08 (30) | 0.08 (16) | 0.07 (21) | 0.09 (25) | 0.06 (16) | 0.10 (30) |
DQB1*05 | 0.15 (54) | 0.24 (47) ** | 0.13 (36) | 0.23 (65) * | 0.17 (42) | 0.19 (59) |
DQB1*06 | 0.20 (74) | 0.22 (42) | 0.20 (55) | 0.22 (61) | 0.21 (52) | 0.21 (64) |