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Table 2 Frequency (f) and number (n) of antibody responders (R) and non-responders (NR) to CS peptide repeats for P. vivax, P. falciparum, and P. malariae according to HLA-DRB1 and HLA-DQB1 genotypes

From: Evaluating seroprevalence to circumsporozoite protein to estimate exposure to three species of Plasmodium in the Brazilian Amazon

  PvCS PfCS PmCS
R NR R NR R NR
f (n) f (n) f (n) f (n) f (n) f (n)
HLA-DRB1
 DRB1*01 0.05 (18) 0.15 (30) *** 0.04 (12) 0.13 (36) *** 0.06 (15) 0.11 (33)
 DRB1*03 0.06 (23) 0.05 (9) 0.06 (17) 0.05 (15) 0.06 (16) 0.05 (16)
 DRB1*04 0.16 (59) 0.15 (29) 0.18 (52) 0.13 (36) 0.14 (35) 0.17 (53)
 DRB1*07 0.12 (43) 0.08 (16) 0.13 (36) 0.08 (23) 0.11 (27) 0.10 (32)
 DRB1*08 0.07 (27) 0.10 (19) 0.09 (25) 0.08 (21) 0.09 (23) 0.07 (23)
 DRB1*09 0.02 (9) 0.03 (6) 0.02 (6) 0.03 (9) 0.02 (6) 0.03 (9)
 DRB1*10 0.03 (12) 0.02 (3) 0.01 (4) 0.04 (11) 0.03 (7) 0.03 (8)
 DRB1*11 0.11 (40) 0.10 (19) 0.10 (27) 0.12 (32) 0.12 (31) 0.09 (28)
 DRB1*12 0.01 (2) 0.03 (5) 0.01 (3) 0.01 (4) 0.01 (3) 0.01 (4)
 DRB1*13 0.15 (56) 0.11 (22) 0.15 (41) 0.13 (37) 0.14 (34) 0.14 (44)
 DRB1*14 0.04 (16) 0.04 (7) 0.05 (13) 0.04 (10) 0.04 (9) 0.05 (14)
 DRB1*15 0.09 (33) 0.10 (19) 0.08 (23) 0.10 (29) 0.10 (26) 0.08 (26)
 DRB1*16 0.08 (28) 0.05 (10) 0.08 (23) 0.05 (15) 0.07 (18) 0.06 (20)
HLA-DQB1
 DQB1*02 0.17 (62) 0.12 (24) 0.19 (53)* 0.12 (33) 0.17 (43) 0.14 (43)
 DQB1*03 0.40 (145) 0.34 (65) 0.41 (116) 0.34 (94) 0.38 (96) 0.37 (114)
 DQB1*04 0.08 (30) 0.08 (16) 0.07 (21) 0.09 (25) 0.06 (16) 0.10 (30)
 DQB1*05 0.15 (54) 0.24 (47) ** 0.13 (36) 0.23 (65) * 0.17 (42) 0.19 (59)
 DQB1*06 0.20 (74) 0.22 (42) 0.20 (55) 0.22 (61) 0.21 (52) 0.21 (64)
  1. The association was verified sing a Fisher’s exact test 2 × 2 contingency table; *P < 0.01, ** P < 0.001, *** P < 0.0001. Each individual contributed with two HLA allele observations