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Table 1 Summary of included references evaluating risk factors for cholangiocarcinoma

From: Thinking beyond Opisthorchis viverrini for risk of cholangiocarcinoma in the lower Mekong region: a systematic review and meta-analysis

Reference Year Country Source of patients or samples Study design Sample size: cases/controls Risk factor categories reported Measure of effect
Parkin et al. [22] 1991 Thailand Maharat Nakorn Ratchasima Hospital, Ubon Ratchathani Hospital, National Cancer Institute case-control 103/103 behaviors, socioeconomics, diet, immune response, other infection odds ratio
Itoh et al. [35] 1994 Thailand/ Japan Khon Kaen province hospitals, Japan case-control 47/68 immune response, gender mean or proportion difference
Haswell-Elkins et al. [46] 1994 Thailand Villages in Khon Kaen and Mahasarkham provinces cross-sectional survey 15 CCA cases of 1807 patients screened gender odds ratio
Honjo et al. [23] 2005 Thailand Nakhon Phanom province hospitals case-control 129/129 behaviors, socioeconomics, diet, genetics, treatment odds ratio
Jinawath et al. [31] 2006 Thailand/ Japan Srinagarind Hospital and Kyoto University Hospital case-control 20/10 genetics median gene expression
Marahatta et al. [55] 2006 Thailand LFCRC Repositorya case-control 30/30 genetics odds ratio
Prawan et al. [29] 2005 Thailand Srinagarind Hospital case-control 216/233 genetics odds ratio
Poomphakwaen et al. [2] 2009 Thailand Khon Kaen Cohort Study nested case-control 108/108 behaviors, diet, treatment, genetics odds ratio
Srivatanakul et al. [38] 2010 Thailand Nakhon Phanom province hospitals case-control 106/106 other infections, immune response odds ratio
Songserm et al. [27] 2011 Thailand Khon Kaen Cohort Study nested case-control 219/438 genetics, diet, socioeconomics odds ratio
Sripa et al. [37] 2012 Thailand Khon Kaen area villages, non-OV endemic Thailand, LFCRC Repositorya case-control 121/21 immune response odds ratio
Yongvanit et al. [32] 2012 Thailand Khon Kaen province hospitals case-control 13/10 genetics mean difference
Songserm et al. [24] 2012 Thailand Khon Kaen Cohort Study nested case-control 219/438 behaviors, socioeconomics, diet, genetics odds ratio
Zeng et al. [30] 2013 Thailand Ubon Ratchathani Cancer Center Hospital case-control 105/105 genetics odds ratio
Manwong et al. [25] 2013 Thailand Sappasit Prasong Hospital and Ubon Ratchathani Cancer Center case-control 123/123 socioeconomics, diet, treatment, behaviors, immune response odds ratio
Plieskatt et al. [33] 2014 Thailand LFCRC Repositorya case-control 16/13 genetics mean difference
Songserm et al. [26] 2014 Thailand Khon Kaen Cohort Study case-control 219/438 behaviors, genetics odds ratio
Prayong et al. [34] 2014 Thailand Srinagarind Hospital and community case-control 79/80 genetics odds ratio
  1. aLiver Fluke and Cholangiocarcinoma Research Center (LFCRC) Biological Repository, Khon Kaen University, Thailand