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Table 2 Dietary risk factors and association with CCA

From: Thinking beyond Opisthorchis viverrini for risk of cholangiocarcinoma in the lower Mekong region: a systematic review and meta-analysis

 

Food

Odds ratio

95% CI

Casesa

Comparison

Source

Raw fish dishes

 

koi pla

10.2

3.05–34.1

77

never vs daily

Songserm 2012 [24]

 

raw cyprinoid fish

3.4

1.05–11.01

100

no or <  1/month vs 3/week

Manwong 2013 [25]

 

raw fish

2.94

1.24–6.96

75

none vs > 2/month

Honjo 2005 [23]

 

koi pla

2.5

1.05–5.74

104

never vs weekly

Songserm 2012 [24]

 

koi pla

1.6

0.7–3.5

97

< monthly vs more

Parkin 1991 [22]

Fermented fish or meat dishes

 

nitrate containing foodsb

4.91

1.04–23.24

216

never vs often

Poomphakwaen 2009 [2]

 

fermented fish or pork

4.5

1.3–15.54

71

none vs > 2/month

Honjo 2005 [23]

 

beef sausage

3.7

1.28–10.7

95

never vs daily

Songserm 2012 [24]

 

cooked pla ra

3

0.31–28.84

34

no or <  1/month vs 1–4/week

Manwong 2013 [25]

 

pla ra, pla chao

2.25

0.92–5.53

129

<  3/day vs > 3/day

Honjo 2005 [23]

 

sour shrimp

1.93

0.47–7.93

101

no or <  1/month vs 3/week

Manwong 2013 [25]

 

uncooked pla ra

1.75

0.74–4.19

86

no or <  1/month vs 3/week

Manwong 2013 [25]

 

pla ra

1.6

0.9–2.8

96

<  3/daily vs more

Parkin 1991 [22]

 

pla chom

1.6

0.57–4.51

94

no or <  1/month vs 3/week

Manwong 2013 [25]

 

sour beef or pork

1.37

0.51–3.65

88

no or <  1/month vs 3/week

Manwong 2013 [25]

 

Chinese or Northeast sausage

1.3

0.51–3.35

103

none vs > 1/month

Honjo 2005 [23]

 

salted fish or meat

1.01

0.41–2.44

113

none vs > 6/year

Honjo 2005 [23]

 

pla chom

1

0.5–1.9

98

< monthly vs more

Parkin 1991 [22]

 

pla som

0.7

0.4–1.3

97

never vs ever

Parkin 1991 [22]

 

salted fish

0.5

0.2–0.9

96

< monthly vs more

Parkin 1991 [22]

 

pla chao

0.5

0.2–1.4

98

< monthly vs more

Parkin 1991 [22]

Other fish and seafood

 

total fish and shellfish

1.31

0.56–3.04

147

< 0.4 vs > 0.8/day

Poomphakwaen 2009 [2]

 

raw shellfish

0.85

0.27–2.74

97

no or <  1/month vs 3/week

Manwong 2013 [25]

Fresh meat dishes

 

raw beef or pork

3.38

1.25–9.12

91

no or <  1/month vs 3/week

Manwong 2013 [25]

 

raw sausage

1.19

0.48–2.97

86

no or < 1/month vs 3/week

Manwong 2013 [25]

 

roast meat

0.74

0.25–2.18

78

<  2/week vs > 1/day

Honjo 2005 [23]

 

poultry

0.62

0.23–1.7

216

< 0.2 vs > 0.4/day

Poomphakwaen 2009 [2]

 

beef and pork

0.31

0.08–1.2

216

<  0.45 vs > 1/day

Poomphakwaen 2009 [2]

Fruits and vegetables

 

fruit

1.72

0.85–3.47

98

no or < 1/month vs 3/week

Manwong 2013 [25]

 

fresh fruit

1.63

0.64–4.12

107

<  1/week vs > 2/week

Honjo 2005 [23]

 

cooked fresh vegetables

1.48

0.62–3.51

110

<  3/week vs > 1/day

Honjo 2005 [23]

 

vegetables

1.36

0.61–3.02

95

no or < 1/month vs 3/week

Manwong 2013 [25]

 

fermented vegetables or fruits

1.18

0.44–3.2

86

<  4/week vs > 2/day

Honjo 2005 [23]

 

fruit

0.7

0.33–0.98

219

<  52 vs > 52 times/month

Songserm 2012 [24]

 

fresh vegetables

0.67

0.27–1.67

95

<  1/week vs > 2/day

Honjo 2005 [23]

 

vegetables

0.6

0.27–1.36

190

< 1.7 vs > 1.7/day

Poomphakwaen 2009 [2]

 

fresh fruit

0.5

0.3–0.9

93

<  3/month vs more

Parkin 1991 [22]

 

fruit

0.44

0.23–0.85

156

< 1 vs > 1/day

Poomphakwaen 2009 [2]

 

vegetables

0.4

0.23–0.76

219

<  52 vs > 52/month

Songserm 2012 [24]

Grains

 

sticky rice

2.6

1.4–4.9

94

<  2/week vs more

Parkin 1991 [22]

 

rice

1.35

0.55–3.27

99

<  4/year vs > 3/month

Honjo 2005 [23]

 

sticky rice

1.03

0.47–2.24

125

<  3/day vs > 3/day

Honjo 2005 [23]

 

rice

0.7

0.4–1.2

94

<  3/day vs more

Parkin 1991 [22]

Betel nut

 

betel nut

6.4

1.1–39.3

n/a

< 1/day vs more

Parkin 1991 [22]

 

betel nut

3

0.81–11.08

123

yes or no

Manwong 2013 [25]

 

betel nut

0.69

0.18–2.7

122

regular vs never chewing

Honjo 2005 [23]

Other

 

somtam

1.9

0.55–6.62

42

never vs daily

Songserm 2012 [24]

 

monosodium glutamate

1.8

1.0–3.2

97

<  2/day vs more

Parkin 1991 [22]

 

milk

0.5

0.3–0.9

95

< monthly vs more

Parkin 1991 [22]

  1. Foods in each category are organized by odds ratio in descending order
  2. aNumber of CCA cases included in the comparison
  3. bNitrate containing foods are fermented and salted items that are high in volatile nitrosamines