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Table 1 Baseline characteristics of 919 children enrolled in the study

From: Parasite reduction ratio one day after initiation of artemisinin-based combination therapies and its relationship with parasite clearance time in acutely malarious children

Variables

AA

(n = 295)

AL

(n = 303)

DHP

(n = 321)

All

(n = 919)

P value

Male:Female

153:142

159:144

183:138

495:424

0.37

Age (month)

 Mean

39

40.5

38.5

39.3

0.3

 95% CI

37.2–40.9

38.6–42.3

36.6–40.3

38.3–40.4

 

 No. ≤ 12 months (%)

23 (7.8)

18 (5.9)

29 (9)

70 (7.6)

0.35

Duration of illness (day)

 Mean

4.2

3.8

3.9

4

0.54

 95% CI

3.7–4.7

3.3–4.3

3.5–4.3

3.7–4.2

 

Weight (kg)

 Mean

13.4

13.5

13.3

13.3

0.18

 95% CI

13–13.9

13–14

13–13.6

13–13.6

 

Temperature (°C)

 Mean

37.8

37.9

37.8

37.8

0.44

 95% CI

37.6–37.9

37.8–38

37.7–37.9

37.7–37.9

 

No. with

  ≥ 37.5 °C (%)*

182 (61.7)

195 (64.4)

193 (60.1)

570 (62)

0.55

  ≥ 40 °C (%)

21 (7)

22 (7.3)

28 (8.7)

81 (8.8)

0.37

Haematocrit (%)

 Mean

30.5

30.3

30.9

30.6

0.3

 95% CI

29.9–31.1

29.7–30.9

30.3–31.5

30.3–30.9

 

No with anaemia (%)

113 (38.3)

120 (39.6)

104 (32.4)

337 (36.7)

0.16

 Mild (%)

106 (35.9)

110 (36.3)

91 (28.3)

307 (33.4)

0.06

 Moderate (%)

6 (2)

10 (3.3)

13 (4)

29 (3.2)

0.35

 Severe (%)

1 (0.3)

0 (0)

0 (0)

1 (0.1)

–

Parasitaemia (/μl)

 Geometric mean

15 518

16 254

15 185

15 638

0.87

 Range

2000–200 000

2003–200 000

2000–200 000

2000–200 000

 

 Gametocytaemia (%)

20 (6.8)

9 (3)

19 (5.9)

48 (5.2)

0.09

  1. *Overall, 570 children were febrile at presentation. Geometric mean enrolment parasitaemia was significantly higher in febrile compared to non-febrile children (20 506/μl [range: 2000–200 000; n = 570] versus 10 045/μl [2000–198 200; n = 349], respectively; P < 0.0001)
  2. AL: Artemether-lumefantrine; AA: Artesunate-amodiaquine; DHP: Dihydroartemisinin-piperaquine; CI: Confidence interval