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Table 2 Predictors of parasite reduction ratio > 5000 one day after initiation of artemisinin-based combination therapies in acutely young malarious children

From: Parasite reduction ratio one day after initiation of artemisinin-based combination therapies and its relationship with parasite clearance time in acutely malarious children

Variable

Total No.

No. with PRRD1 > 5000

OR (95% CI)

P value

aOR (95% CI)

P value

Gender

 Female

424

119

1

   

 Male

495

135

1.0 (0.7–1.3)

0.85

–

–

Age (month)

  ≤ 15

103

19

1

 

1

 

  > 15

810

232

1.8 (1.1–3.0)

0.04

2.0 (1.0–4.1)

0.048

Duration of illness (days)

  ≤ 2

269

82

1

   

  > 2

334

121

1.3 (0.9–1.8)

0.16

–

–

Haematocrit at presentation (%)

  < 30

652

170

1

 

1

 

  ≥ 30

247

83

1.4 (1.0–2.0)

0.03

1.2 (0.8–1.9)

0.3

Haematocrit on day 1 (%)

  ≥ 30

483

130

1

   

  < 30

407

120

1.1 (0.8–1.5)

0.44

–

–

History of fever before treatment

 Absent

170

41

1

   

 Present

749

213

1.3 (0.9–1.9)

0.3

–

–

Temperature at presentation (°C)

  ≤ 37.4

349

88

1

   

  > 37.4

570

166

1.2 (0.9–1.6)

0.23

–

–

Fever on day 1*

 Absent

797

225

1

   

 Present

103

26

0.9 (0.5–1.4)

0.6

–

–

Enrolment Parasitaemia

  ≤ 104

370

44

1

 

1

 

  > 104

349

210

4.6 (3.2–6.6)

< 0.0001

4.8 (3.0–7.5)

< 0.0001

Gametocytaemia

 Absent

871

243

1

   

 Present

48

11

0.8 (0.4–1.5)

0.56

–

–

Drug treatment

 AL

303

68

1

   

 AA

295

85

1.4 (1.0–2.0)

0.09

–

–

 DHP

321

101

1.6 (1.1–2.3)

0.01

1.8 (1.2–2.6)

0.003

  1. PRRD1 Parasite reduction ratio 1 day post-treatment initiation, AL Artemether-lumefantrine, AA Artesunate-amodiaquine, DHP Dihydroartemisinin-piperaquine, CI Confidence interval, OR Odd ratio, aOR Adjusted odd ratio
  2. *Fever 1 day post-treatment initiation