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Table 2 Predictors of parasite reduction ratio > 5000 one day after initiation of artemisinin-based combination therapies in acutely young malarious children

From: Parasite reduction ratio one day after initiation of artemisinin-based combination therapies and its relationship with parasite clearance time in acutely malarious children

Variable Total No. No. with PRRD1 > 5000 OR (95% CI) P value aOR (95% CI) P value
Gender
 Female 424 119 1    
 Male 495 135 1.0 (0.7–1.3) 0.85
Age (month)
  ≤ 15 103 19 1   1  
  > 15 810 232 1.8 (1.1–3.0) 0.04 2.0 (1.0–4.1) 0.048
Duration of illness (days)
  ≤ 2 269 82 1    
  > 2 334 121 1.3 (0.9–1.8) 0.16
Haematocrit at presentation (%)
  < 30 652 170 1   1  
  ≥ 30 247 83 1.4 (1.0–2.0) 0.03 1.2 (0.8–1.9) 0.3
Haematocrit on day 1 (%)
  ≥ 30 483 130 1    
  < 30 407 120 1.1 (0.8–1.5) 0.44
History of fever before treatment
 Absent 170 41 1    
 Present 749 213 1.3 (0.9–1.9) 0.3
Temperature at presentation (°C)
  ≤ 37.4 349 88 1    
  > 37.4 570 166 1.2 (0.9–1.6) 0.23
Fever on day 1*
 Absent 797 225 1    
 Present 103 26 0.9 (0.5–1.4) 0.6
Enrolment Parasitaemia
  ≤ 104 370 44 1   1  
  > 104 349 210 4.6 (3.2–6.6) < 0.0001 4.8 (3.0–7.5) < 0.0001
Gametocytaemia
 Absent 871 243 1    
 Present 48 11 0.8 (0.4–1.5) 0.56
Drug treatment
 AL 303 68 1    
 AA 295 85 1.4 (1.0–2.0) 0.09
 DHP 321 101 1.6 (1.1–2.3) 0.01 1.8 (1.2–2.6) 0.003
  1. PRRD1 Parasite reduction ratio 1 day post-treatment initiation, AL Artemether-lumefantrine, AA Artesunate-amodiaquine, DHP Dihydroartemisinin-piperaquine, CI Confidence interval, OR Odd ratio, aOR Adjusted odd ratio
  2. *Fever 1 day post-treatment initiation