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Fig. 1 | Infectious Diseases of Poverty

Fig. 1

From: Detection of helminths by loop-mediated isothermal amplification assay: a review of updated technology and future outlook

Fig. 1

Principle of LAMP. The initiative stage of LAMP assay: Besides the target DNA, the reaction system in (a) contains a set of inner primers—BIP and FIP, and a set of outer primers –F3 and B3 primer. An inner primer initiates the reaction in (b-g) by replacing the template strand with the help of polymerase with strand-displacement activity such as Bst DNA polymerase. An outer primer working, a single strand DNA is released, serving as the template of the following reaction. The similar strand-displacing DNA synthesis proceeding in the other end, yields the dumbbell-like DNA strands with a stem-loop structure in (g), which take part in the auto-cycling stage

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Infectious Diseases of Poverty

ISSN: 2049-9957

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