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Table 3 Univariate and multivariate analysis of factors associated with HBV infection among children born to HBsAg-positive mothers in four provinces, China 2016–2017

From: Outcomes of the national programme on prevention of mother-to-child transmission of hepatitis B virus in China, 2016–2017

Characteristics

Number of observations

HBsAg Positive

Univariate analysis

Multivariable analysis

N(%)

OR(95% CI)

P-value

aOR(95% CI)

P-value

Maternal age (years)

 18–24

280

3(1.1)

2.3 (0.5–10.2)

0.2#

  

 25–34

2992

28(0.9)

2.0 (0.7–5.6)

   

 35–45

840

4(0.5)

1

   

Maternal educational level

 Junior middle school and below

1382

12(0.9)

1.0 (0.5–2.1)

0.9

  

 High middle school and above

2730

23(0.8)

1

   

Maternal residence rural / urban

 Rural

2818

28(1.0)

1.8 (0.8–4.2)

0.1

  

 Urban

1294

7(0.5)

1

   

Maternal parity

 1

1732

18(1.0)

1.5 (0.8–2.8)

1.3

  

  > 1

2380

17(0.7)

1

   

Maternal HBeAg status during this pregnancy

 Positive

1221

33(2.7)

76.1 (10.4–556.9)

<  0.001#

79.1 (10.8–580.2)

<  0.001

 Negative

2740

1(0.04)

1

 

1

 

 Unknown

151

1(0.7)

18.3 (1.1–293.4)

 

16.7 (1.0–269.6)

0.05

Maternal antiviral treatment during this pregnancy

 Yes

392

1(0.3)

0.3 (0.0–2.0)

0.25*

  

 No

3720

34(0.9)

1

   

Level of delivery hospital

 County level and below

2594

29(1.1)

2.8 (1.2–6.9)

0.02

3.3 (1.3–8.0)

0.01

 Prefectural and above

1518

6(0.4)

1

 

1

 

Mode of delivery

 Vaginal delivery

2349

23(1.0)

1.4 (0.72–2.9)

0.3

  

 Caesarean section

1763

12(0.7)

1

   

Child gender

 Male

2185

17(0.8)

0.8 (0.4–1.6)

0.6

  

 Female

1927

18(0.9)

1

   

Gestational age (weeks)

  < 37

236

3(1.3)

1.5 (0.5–5.1)

0.5*

  

 37–43

3876

32(0.8)

    

Child birth weight (g)

  < 2500 (LBW)

131

3(2.3)

2.9 (0.9–9.6)

0.09*

2.7 (0.8–9.7)

0.1

 2500–5400

3981

32(0.8)

1

 

1

 

Type of HBvacc–BD

 10 μg yeast vaccine

3637

29(0.8)

0.8 (0.2–3.2)

0.5

  

 20 μg CHO vaccine

285

4(1.4)

1.3 (0.2–7.4)

   

 10 μg CHO vaccine

190

2(1.1)

1

   

Interval between birth and HBvac-BD (hours)

 Within 12

3579

23(0.6)

1

0.001#

1

 

 12–24

466

11(2.4)

3.7 (1.8–7.7)

 

2.9 (1.4–6.3)

0.01

  > 24

67

1(1.5)

2.4 (0.3–17.6)

 

2.1 (0.3–17.7)

0.5

Administered HBIG

 Yes

4092

35(0.9)

0.99 (0.98–0.99)

1.0*

  

 No

20

0(0.0)

1

   

Interval between 3rd dose HBvacc and HBV serological marker test (months)

  < 7

1666

12(0.7)

0.8 (0.4–1.5)

0.5

  

 7–18

2446

23(0.9)

1

   
  1. HBV hepatitis B virus, HBsAg hepatitis B surface antigen, HBeAg HBV e antigen, HBvacc hepatitis B vaccine, HBvacc-BD hepatitis B vaccine birth dose, HBIG hepatitis B immunoglobulin, LBW low birth weight, CHO Chinese hamster ovary, #: trend, *: Fisher’s exact test, OR odds ratio, aOR adjusted odds ratio, factors significant at P <  0.1 in univariate analysis entered into the regression model)