Variable | Total number | Number with APPD2 | OR (95% CI) | P value | aOR (95% CI) | P value |
---|---|---|---|---|---|---|
Gender | ||||||
 Female | 615 | 92 | 1 |  |  |  |
 Male | 726 | 99 | 0.9 (0.7–1.2) | 0.54 | – | – |
Age [month] | ||||||
  > 24 | 963 | 138 | 1 |  |  |  |
  ≤ 24 | 378 | 53 | 1.0 (0.7–1.4) | 0.95 | – | – |
Temperature at presentation (°C) | ||||||
  ≤ 40 | 1263 | 172 | 1 |  |  |  |
  > 40 | 78 | 19 | 2.0 (1.2–3.5) | 0.01 | 1.0 (0.5–1.9) | 0.97 |
Fever on day 1 | ||||||
 Absent | 1189 | 152 | 1 |  |  |  |
 Present | 132 | 32 | 2.2 (1.4–3.4) | 0.001 | 1.8 (1.1–3.2) | 0.03 |
Haematocrit at presentation (%) | ||||||
  < 30 | 728 | 115 | 1 |  |  |  |
  ≥ 30 | 526 | 65 | 0.8 (0.5–1.0) | 0.1 | – | – |
Haematocrit on day 1 (%) | ||||||
  ≤ 29 | 405 | 58 | 1 |  | 1 |  |
  > 29 | 510 | 102 | 1.5 (1.1–2.1) | 0.01 | 1.7 (1.1–2.5) | 0.01 |
Enrolment Parasitaemia (μl−1) | ||||||
  ≤ 100 000 | 1211 | 162 | 1 |  | 1 |  |
  > 100 000 | 130 | 29 | 1.9 (1.2–2.9) | 0.008 | 1.4 (0.8–2.5) | 0.22 |
Parasitaemia on day 1 | ||||||
 Absent | 573 | 19 | 1 |  | 1 |  |
 Present | 768 | 172 | 8.4 (5.2–13.7) | <  0.0001 | 9.3 (5.2–16.6) | <  0.0001 |
Gametocytaemia | ||||||
 Present | 188 | 13 | 1 |  |  |  |
 Absent | 1029 | 178 | 2.8 (1.6–5.1) | <  0.0001 | 1.4 (0.5–3.5) | 0.53 |
Drug treatment | ||||||
 AA | 678 | 87 | 1 |  |  |  |
 AL | 663 | 104 | 1.3 (0.9–1.7) | 0.16 | – | – |
Period of enrolment | ||||||
 2009–2010 | 743 | 38 | 1 |  |  |  |
 2014–2015 | 598 | 153 | 6.4 (4.4–9.3) | <  0.0001 | 3.0 (1.7–5.1) | <  0.0001 |