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Table 2 Diagnostic performance of three RDTs under evaluation for the detection of Cryptosporidium spp. and/or Giardia duodenalis infection in stool samples of children under the age of 5 years from Kenya or Malawi

From: Performance of three rapid diagnostic tests for the detection of Cryptosporidium spp. and Giardia duodenalis in children with severe acute malnutrition and diarrhoea

   Sensitivity (95% CI)Specificity (95% CI)AUCPPV (95% CI)NPV (95% CI)
RIDA-CryptosporidiumKenya76.9% (56.491.0%)89.4% (81.394.8%)0.83166.7% (51.878.6%)93.3% (87.496.6%)
QUICK Malawi66.7% (43.0–85.4%)88.4% (80.294.1%)0.74656.0% (40.370.1%)92.3% (86.795.7%)
  Both countries72.3% (57.484.4%)88.9% (83.593.0%)0.79361.8% (51.071.6%)92.8% (89.095.4%)
 GiardiaKenya71.4% (29.096.4%)91.2% (84.395.7%)0.81733.3% (19.051.5%)98.1% (94.199.4%)
  Malawi48.2% (28.768.1%)93.3% (85.997.5%)0.72568.4% (47.783.3%)85.6% (80.489.5%)
  Both countries52.9% (35.170.2%)92.1% (87.595.4%)0.74252.9% (39.066.5%)92.1% (89.094.3%)
DUO-CryptosporidiumKenya69.2% (48.285.7%)100% (96.2100%)0.846100%92.2% (86.895.4%)
Strip Malawi42.9% (21.866.0%)95.8% (89.698.8%)0.68869.2% (43.386.9%)88.4% (83.991.7%)
  Both countries57.5% (42.271.7%)97.9% (94.799.4%)0.77487.1% (71.394.8%)90.2% (85.393.4%)
 GiardiaKenya57.1% (18.490.1%)94.7% (88.898.0%)0.75940.0% (19.664.6%)97.3% (93.898.8%)
  Malawi51.8% (32.071.3%)96.6% (90.599.3%)0.74282.4% (59.293.8%)86.9% (81.790.7%)
  Both countries52.9% (35.170.2%)95.5% (91.797.4%)0.74266.7% (49.580.3%)92.3% (89.494.5%)
QUIK-CryptosporidiumKenya76.9% (56.491.0%)100% (96.2100%)0.885100%94.0% (88.696.9%)
CHEK Malawi61.9% (38.481.9%)96.8% (91.199.3%)0.79481.3% (57.593.3%)92.0% (86.995.2%)
  Both countries70.2% (55.182.7%)98.4% (95.499.7%)0.84391.7% (77.997.2%)93.0% (89.595.4%)
 GiardiaKenya85.7% (42.199.6%)99.2% (95.2100%)0.92085.7% (45.497.7%)99.1% (94.899.9%)
  Malawi81.5% (61.993.7%)96.6% (90.599.3%)0.89688.0% (70.495.8%)94.5% (88.697.4%)
  Both countries82.4% (65.593.2%)98.0% (95.099.5%)0.90287.5% (72.494.9%)97.1% (94.198.6%)
  1. RDT Rapid diagnostic test, 95% CI 95% Confidence interval, AUC Area under the curve, PPV Positive predictive value, NPV Negative predictive value