Table 2 Diagnostic performance of three RDTs under evaluation for the detection of Cryptosporidium spp. and/or Giardia duodenalis infection in stool samples of children under the age of 5 years from Kenya or Malawi
| Â | Â | Â | Sensitivity (95% CI) | Specificity (95% CI) | AUC | PPV (95% CI) | NPV (95% CI) |
|---|---|---|---|---|---|---|---|
RIDA- | Cryptosporidium | Kenya | 76.9% (56.4–91.0%) | 89.4% (81.3–94.8%) | 0.831 | 66.7% (51.8–78.6%) | 93.3% (87.4–96.6%) |
QUICK |  | Malawi | 66.7% (43.0–85.4%) | 88.4% (80.2–94.1%) | 0.746 | 56.0% (40.3–70.1%) | 92.3% (86.7–95.7%) |
|  |  | Both countries | 72.3% (57.4–84.4%) | 88.9% (83.5–93.0%) | 0.793 | 61.8% (51.0–71.6%) | 92.8% (89.0–95.4%) |
|  | Giardia | Kenya | 71.4% (29.0–96.4%) | 91.2% (84.3–95.7%) | 0.817 | 33.3% (19.0–51.5%) | 98.1% (94.1–99.4%) |
|  |  | Malawi | 48.2% (28.7–68.1%) | 93.3% (85.9–97.5%) | 0.725 | 68.4% (47.7–83.3%) | 85.6% (80.4–89.5%) |
|  |  | Both countries | 52.9% (35.1–70.2%) | 92.1% (87.5–95.4%) | 0.742 | 52.9% (39.0–66.5%) | 92.1% (89.0–94.3%) |
DUO- | Cryptosporidium | Kenya | 69.2% (48.2–85.7%) | 100% (96.2–100%) | 0.846 | 100% | 92.2% (86.8–95.4%) |
Strip |  | Malawi | 42.9% (21.8–66.0%) | 95.8% (89.6–98.8%) | 0.688 | 69.2% (43.3–86.9%) | 88.4% (83.9–91.7%) |
|  |  | Both countries | 57.5% (42.2–71.7%) | 97.9% (94.7–99.4%) | 0.774 | 87.1% (71.3–94.8%) | 90.2% (85.3–93.4%) |
|  | Giardia | Kenya | 57.1% (18.4–90.1%) | 94.7% (88.8–98.0%) | 0.759 | 40.0% (19.6–64.6%) | 97.3% (93.8–98.8%) |
|  |  | Malawi | 51.8% (32.0–71.3%) | 96.6% (90.5–99.3%) | 0.742 | 82.4% (59.2–93.8%) | 86.9% (81.7–90.7%) |
|  |  | Both countries | 52.9% (35.1–70.2%) | 95.5% (91.7–97.4%) | 0.742 | 66.7% (49.5–80.3%) | 92.3% (89.4–94.5%) |
QUIK- | Cryptosporidium | Kenya | 76.9% (56.4–91.0%) | 100% (96.2–100%) | 0.885 | 100% | 94.0% (88.6–96.9%) |
CHEK |  | Malawi | 61.9% (38.4–81.9%) | 96.8% (91.1–99.3%) | 0.794 | 81.3% (57.5–93.3%) | 92.0% (86.9–95.2%) |
|  |  | Both countries | 70.2% (55.1–82.7%) | 98.4% (95.4–99.7%) | 0.843 | 91.7% (77.9–97.2%) | 93.0% (89.5–95.4%) |
|  | Giardia | Kenya | 85.7% (42.1–99.6%) | 99.2% (95.2–100%) | 0.920 | 85.7% (45.4–97.7%) | 99.1% (94.8–99.9%) |
|  |  | Malawi | 81.5% (61.9–93.7%) | 96.6% (90.5–99.3%) | 0.896 | 88.0% (70.4–95.8%) | 94.5% (88.6–97.4%) |
|  |  | Both countries | 82.4% (65.5–93.2%) | 98.0% (95.0–99.5%) | 0.902 | 87.5% (72.4–94.9%) | 97.1% (94.1–98.6%) |