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Table 3 The accuracy performance of RDBH assay compared to sequencing in Mycobacterium tuberculosis clinical strains

From: Accuracy of a reverse dot blot hybridization assay for simultaneous detection of the resistance of four anti-tuberculosis drugs in Mycobacterium tuberculosis isolated from China

Drug

Sequencing

RDBH assay

R

S

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

Concordance (%)

Kappa value

RIF

M

170

4

97.7

97.9

98.3

97.3

97.8

0.96

 

W

3

143

      

INH

M

189

4

97.9

100.0

100.0

96.9

98.8

0.97

 

W

0

127

      

SM

M

134

3

97.8

100.0

100.0

98.4

99.1

0.98

 

W

0

183

      

EMB

M

90

19

82.6

99.1

97.8

91.7

93.4

0.85

 

W

2

209

      
  1. M Mutated, W Wild type, S Susceptible, R Resistant, PPV Positive predictive value; NPV, Negative predicte value, RIF Rifampicin, INH Isoniazid, SM Streptomycin, EMB Ethambutol, RDBH Reverse dot blot hybridization