Mannose-binding lectin 2 gene polymorphisms and their association with tuberculosis in a Chinese population

Table 4 Haplotypes analysis of MBL2 gene polymorphisms with tuberculosis risk

Haplotype	Tuberculosis		Control		P^a	P_adjusted^b	Hap. Score^c	Logistic Regression		Global score test
Haplotype	No.	Frequency	No.	Frequency	P^a	P_adjusted^b	Hap. Score^c	OR (95% CI)	P^d	Global score test
Block 1: rs10824793-rs7916582										Global-stat = 14.57143, df ^e = 3, P = 0.00222, P_sim = 0.00207
AT	1328	66.3%	723	71.4%	0.00014	0.00042	−3.8039	1.000 (referent)
GT	423	21.1%	177	17.5%	0.003	0.009	2.9843	1.421 (1.152–1.753)	0.001
GC	248	12.4%	111	11.0%	0.077	0.231	1.7679	1.364 (1.055–1.765)	0.018
Others	3	0.2%	1	0.1%	–	–	–	–	–

^aP value for difference in the haplotype frequency between tuberculosis and control group
^bP_adjusted, P value with Bonferroni correction, P_adjusted value less than 0.05 was considered to be significant
^cA positive (or negative) score for a particular haplotype would have suggested that the haplotype was associated with increased (or decreased) risk of Tuberculosis
^dP values from unconditional logistic regression analyses, adjusted for age and gender
^edf degrees of freedom

ISSN: 2049-9957