Table 3 Comparison of cytokine levels in patients with acute and chronic brucellosis
From: IL-6 and INF-γ levels in patients with brucellosis in severe epidemic region, Xinjiang, China
Clinical indicators | Acute group (n = 50) | Chronic group (n = 141) | t/χ2/z | P-value |
|---|---|---|---|---|
Age (years), mean ± SD | 40 ± 14 | 44 ± 14 | 1.813(t) | 0.071 |
Gender, n (%) | 36 (72.0) | 98 (69.5) | 0.740 (χ2) | 0.109 |
Brucellosis arthritis, n (%) | 23 (46.0) | 89 (63.1) | 4.460 (χ2) | 0.035 |
Lumbar disc hyperplasia, n (%) | 23 (46.0) | 76 (54.0) | 0.922 (χ2) | 0.337 |
Chronic cholecystitis, n (%) | 11 (22.0) | 20 (14.2) | 1.658 (χ2) | 0.198 |
Orchitis, n (%) | 4 (8.0) | 9 (6.4) | 0.152 (χ2) | 0.696 |
Blood culture, positive, n (%) | 20 (40.0) | 23 (16.5) | 11.508 (z) | < 0.001 |
RF (IU/ml) | 7.2 (3.8–9.9) | 6.2 (3.7–9.8) | 0.633 (z) | 0.526 |
ESR (mm/h) | 25 (15–40) | 17 (7–37) | 2.040 (z) | < 0.041 |
anti-O (IU/ml) | 79 (33–137) | 87 (45–182) | 0.717 (z) | 0.473 |
PCT (pg/ml) | 0.08 (0.06–0.12) | 0.04 (0.03–0.06) | 3.914 (z) | < 0.001 |
CRP (mg/L) | 12.6 (5.0–30.8) | 3.3 (1.2–16.2) | 3.931 (z) | < 0.001 |
IL-4 (pg/ml) | 4.03 (1.29–8.08) | 2.02 (0.96–5.90) | 1.874 (z) | 0.061 |
IL-6 (pg/ml) | 65.32 (36.27–68.60) | 29.38 (11.30–53.09) | 3.683 (z) | < 0.001 |
IL-10 (pg/ml) | 2.38 (1.51–3.34) | 0.89 (0.77–1.13) | 3.350 (z) | < 0.001 |
IL-17 (pg/ml) | 11.98 (3.92–16.49) | 5.27 (2.24–12.49) | 2.856 (z) | < 0.004 |
TNF-α (pg/ml) | 50.88 (16.59–96.69) | 28.24 (5.30–64.40) | 2.387 (z) | < 0.017 |
INF-γ (pg/ml) | 319 (145.14–588.52) | 160.52 (36.59–418.54) | 2.979 (z) | < 0.003 |