Table 4 Relationship between Brucella antibody titer and cytokine levels
From: IL-6 and INF-γ levels in patients with brucellosis in severe epidemic region, Xinjiang, China
Clinical indicators | Antibody titer ≤1:100 (n = 112) | Antibody titer > 1:100 (n = 79) | z | P-value |
|---|---|---|---|---|
Blood culture, positive, n (%) | 17 (15.3) | 26 (33.3) | 8.462 | < 0.004 |
RF (IU/ml) | 3.0 (0.8–9.7) | 13.6 (3.0–31.4) | 4.496 | < 0.001 |
ESR (mm/h) | 15 (7–31) | 27 (15–46) | 4.245 | < 0.001 |
anti-O (IU/ml) | 82.5 (44.5–156.5) | 86.0 (36.0–185.0) | 0.020 | 0.984 |
PCT (pg/ml) | 0.04 (0.03–0.06) | 0.07 (0.04–0.11) | 2.372 | < 0.017 |
CRP (mg/L) | 3.03 (0.85–9.70) | 13.65 (2.97–31.43) | 4.496 | < 0.001 |
IL-4 (pg/ml) | 2.84 (0.98–6.16) | 2.69 (0.97–6.25) | 0.946 | 0.068 |
IL-6 (pg/ml) | 30.46 (11.30–50.02) | 46.20 (17.72–79.69) | 2.840 | < 0.004 |
IL-10 (pg/ml) | 1.66 (1.14–2.52) | 1.98 (1.15–3.13) | 0.156 | 0.156 |
IL-17 (pg/ml) | 6.54 (2.09–13.37) | 6.77 (2.80–15.27) | 0.942 | 0.346 |
TNF-α (pg/ml) | 37.13 (6.05–61.89) | 36.23 (5.79–86.44) | 0.751 | 0.452 |
INF-γ (pg/ml) | 183.115 (41.59–413.25) | 270.91 (47.03–538.5) | 1.620 | 0.105 |