Pretreatment HIV drug resistance in adults initiating antiretroviral therapy in China, 2017

Table 4 Factors associated with pretreatment HIV drug resistance among HIV-infected individuals initiating ART in 2017 in China

Variable	Number	PDR, N (%)	OR (95% CI)	P-value	aOR (95% CI)	P-value
Total	1711	117 (6.8)
Age (years)
< 25	209	16 (7.7)	1.00
≥ 25	1502	101 (6.7)	0.87 (0.50–1.51)	0.62
Sex
Male	1301	93 (7.2)	1.00
Female	410	24 (5.9)	0.76 (0.48–1.22)	0.26
Marital status
Unmarried	562	38 (6.8)	1.00
Married	873	59 (6.8)	1.00 (0.66–1.53)	0.99
Divorce or widow	271	20 (7.4)	1.10 (0.63–1.93)	0.74
Unknown	5	0 (0.0)	-	0.99
Education
Primary and below	638	52 (8.2)	1.00
Junior high school	496	35 (7.1)	0.86 (0.55–1.34)	0.49
Senior high school	217	14 (6.5)	0.78 (0.42–1.43)	0.42
College	307	15 (4.9)	0.58 (0.32–1.05)	0.07
Unknown	53	1 (1.9)	0.22 (0.03–1.60)	0.13
Route of infection
Heterosexual intercourse	1027	57 (5.6)	1.00		1.00
Homosexual intercourse	453	27 (6.0)	1.08 (0.67–1.73)	0.75	1.48 (0.87–2.52)	0.15
Intravenous drug use	160	28 (17.5)	3.61 (2.22–5.88)	< 0.001	2.64 (1.57–4.44)	< 0.001
Others	71	5 (7.0)	1.29 (0.50–3.33)	0.60	1.56 (0.60–4.08)	0.36
CD4 count before ART (cells/mm³)
< 350	1076	71 (6.6)	1.00
≥ 350	576	45 (7.8)	1.20(0.81–1.77)	0.36
Missing	59	1 (1.7)	0.24(0.03–1.79)	0.17
Subtype
CRF01_AE	559	26 (4.7)	1.00
CRF07_BC	633	49 (7.7)	1.72 (1.05–2.81)	0.03
CRF08_BC	228	19 (8.3)	1.86 (1.01–3.44)	0.05
CRF55_01B	64	8 (12.5)	2.93 (1.27–6.78)	0.01
B	40	1 (2.5)	0.53 (0.07–3.98)	0.53
C	53	5 (9.4)	2.14 (0.78–5.81)	0.14
Others	134	9 (6.7)	1.48 (0.68–3.23)	0.33
Region
Others	1124	55 (4.9)	1.00		1.00
Liangshan, Dehong and Lincang^a	587	62 (10.6)	2.30 (1.57–3.35)	< 0.001	2.04 (1.26–3.30)	0.004

^a: The HIV epidemic was the most severe in Liangshan, Dehong and Lincang. The HIVDR rate was high in these areas
PDR pretreatment drug resistance, OR odds ratio, aOR adjusted odds ratio, CI confidence interval, ART antiretroviral therapy, HIV Human immunodeficiency virus, HIVDR HIV drug resistance; -: Not applicable.

ISSN: 2049-9957