Table 7 Prevalence of dhfr and dhps haplotypes in Plasmodium falciparum isolates from Lagos, Nigeria
Gene | Category | Haplotype | n (%) |
|---|---|---|---|
dhfr | Wild type | CNCSI | 8 (3.3) |
Double mutation | CICNI | 1 (0.4) | |
CNRNI | 3 (1.2) | ||
Triple mutation | CIRNI | 227 (93.8) | |
Quadruple mutation | CIRNIR | 1 (0.4) | |
CIRNIK | 1 (0.4) | ||
CIRNIE | 1 (0.4) | ||
dhps | Single mutation | SGKAA | 74 (44.3) |
AAKAA | 4 (2.4) | ||
Double mutations | AGKAA | 7 (4.2) | |
FAKAS | 3 (1.8) | ||
SGKGA | 2 (1.2) | ||
AAKGA | 1 (0.6) | ||
SGKAS | 6 (3.6) | ||
SGEAA | 2 (1.2) | ||
VSGKAA | 1 (0.6) | ||
Triple mutations | SGKGS | 9 (5.4) | |
VAGKAA | 1 (0.6) | ||
AGKGA | 1 (0.6) | ||
AGKAS | 14 (8.4) | ||
Quadruple | AGKGS | 2 (1.2) | |
VAGKAS | 3 (1.8) | ||
VAGKGA | 4 (2.4) | ||
Quintuple | VAGKGS | 33 (19.8) |