Table 1 Demographic, clinical and molecular characteristics of MDR-TB patients and isolated Mycobacterium tuberculosis strains a
Factors | All patients (n = 58) | Treatment regimen | P value | |
|---|---|---|---|---|
Non-MDR-TB (n = 39) | MDR-TB (n = 19) | |||
Age b | 45.4 ± 17.3 | 49.6 ± 17.6 | 36.8 ± 13.4 | 0.009 |
Male | 49 (84.5) | 36 (92.3) | 13 (68.4) | 0.047 |
Study sites in | ||||
Western | 41 (70.7) | 31 (79.5) | 10 (52.6) | 0.035 |
Eastern | 17 (29.3) | 8 (20.5) | 9 (47.4) | |
Body mass index b | 20.4 ± 2.3 | 20.7 ± 2.3 | 19.8 ± 2.2 | 0.191 |
Education | ||||
Primary school or below | 38 (65.5) | 25 (64.1) | 13 (68.4) | 0.745 |
Junior high school or above | 20 (34.5) | 14 (35.9) | 6 (31.6) | |
Married | 31 (53.4) | 20 (51.3) | 11 (57.9) | 0.636 |
Health insurance | 51 (87.9) | 38 (97.4) | 13 (68.4) | 0.004 |
Haemoptysis | 15 (25.9) | 11 (28.2) | 4 (21.1) | 0.752 |
Tuberculosis treatment history | 25 (43.1) | 19 (48.7) | 6 (31.6) | 0.216 |
Pulmonary cavities | 28 (48.3) | 17 (43.6) | 11 (57.9) | 0.306 |
DST pattern | ||||
MDR | 31 (53.4) | 17 (43.6) | 14 (73.7) | 0.031 |
Pre-XDR and XDR | 27 (46.6) | 22 (56.4) | 5 (26.3) | |
Genotypic drug resistance (n = 52) | ||||
katG/inhA mutation | 38 (73·1) | 22 (62·9) | 16 (94·1) | 0·021 |
rpoB mutation | 49 (94·2) | 32 (91·4) | 17 (100·0) | 0·542 |
gyrA/gyrB mutation | 20 (38·5) | 14 (40·0) | 6 (35·3) | 0·744 |
rrs/eis mutation | 8 (15·4) | 7 (20·0) | 1 (5·9) | 0·248 |
pncA mutation | 14 (26·9) | 11 (31·4) | 3 (17·6) | 0·341 |
Strain family (n = 52) | ||||
Non-Beijing family | 6 (11.5) | 4 (11.4) | 2 (11.8) | 1.000 |
Beijing family | 46 (88.5) | 31 (88.6) | 15 (88.2) | |