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Table 1 Demographic, clinical and molecular characteristics of MDR-TB patients and isolated Mycobacterium tuberculosis strains a

From: Treatment quality and outcome for multidrug-resistant tuberculosis patients in four regions of China: a cohort study

Factors All patients (n = 58) Treatment regimen P value
Non-MDR-TB (n = 39) MDR-TB (n = 19)
Age b 45.4 ± 17.3 49.6 ± 17.6 36.8 ± 13.4 0.009
Male 49 (84.5) 36 (92.3) 13 (68.4) 0.047
Study sites in
 Western 41 (70.7) 31 (79.5) 10 (52.6) 0.035
 Eastern 17 (29.3) 8 (20.5) 9 (47.4)  
Body mass index b 20.4 ± 2.3 20.7 ± 2.3 19.8 ± 2.2 0.191
Education
 Primary school or below 38 (65.5) 25 (64.1) 13 (68.4) 0.745
 Junior high school or above 20 (34.5) 14 (35.9) 6 (31.6)  
Married 31 (53.4) 20 (51.3) 11 (57.9) 0.636
Health insurance 51 (87.9) 38 (97.4) 13 (68.4) 0.004
Haemoptysis 15 (25.9) 11 (28.2) 4 (21.1) 0.752
Tuberculosis treatment history 25 (43.1) 19 (48.7) 6 (31.6) 0.216
Pulmonary cavities 28 (48.3) 17 (43.6) 11 (57.9) 0.306
DST pattern
 MDR 31 (53.4) 17 (43.6) 14 (73.7) 0.031
 Pre-XDR and XDR 27 (46.6) 22 (56.4) 5 (26.3)  
Genotypic drug resistance (n = 52)
katG/inhA mutation 38 (73·1) 22 (62·9) 16 (94·1) 0·021
rpoB mutation 49 (94·2) 32 (91·4) 17 (100·0) 0·542
gyrA/gyrB mutation 20 (38·5) 14 (40·0) 6 (35·3) 0·744
rrs/eis mutation 8 (15·4) 7 (20·0) 1 (5·9) 0·248
pncA mutation 14 (26·9) 11 (31·4) 3 (17·6) 0·341
Strain family (n = 52)
 Non-Beijing family 6 (11.5) 4 (11.4) 2 (11.8) 1.000
 Beijing family 46 (88.5) 31 (88.6) 15 (88.2)  
  1. DNA was failure to extract from six Mycobacterium tuberculosis isolates. MDR Multidrug-resistant, DST Drug susceptibility testing, XDR Extensively drug-resistant
  2. aData are presented as number (percent) unless other specifies
  3. bContinuous variable; means ± standard deviations are presented