Table 2 Antigen-specific cytokine profile of peripheral blood mononuclear cells from leprosy patients, household contacts and healthy controls
Parameters | Groups | Subgroups | ||||
|---|---|---|---|---|---|---|
Healthy controls | Leprosy | HHC | Leprosy | |||
HHC(PB) | HHC(MB) | L(PB) | L(MB) | |||
Proportion of subjects with biomarker INDEX above the global median cut-off# | ||||||
T-cells | ||||||
IFN-γ+ | 46 (11/24) | 50 (05/10) | 44 (04/09) | 50 (03/06) | 67 (04/06) | 25 (01/04) |
IL-4+ | 50 (12/24) | 47 (08/17) | 44 (04/09) | 33 (02/06) | 57 (04/07) | 40 (04/10) |
IL-10+ | 47 (14/30) | 55 (06/11) | 64 (07/11) | 50 (05/10) | 57 (04/07) | 50 (02/04) |
CD4+T-cells | ||||||
IFN-γ+ | 42 (10/24) | 50 (05/10) | 44 (04/09) | 67 (04/06) | 50 (03/06) | 50 (02/04) |
IL-4+ | 39 (09/23) | 69 (11/16)a | 33 (03/09) | 20 (01/05) | 57 (04/07) | 78 (07/09)e |
IL-10+ | 47 (14/30) | 73 (08/11) | 55 (06/11) | 40 (04/10) | 86 (06/07) | 50 (02/04) |
CD8+T-cells | ||||||
IFN-γ+ | 39 (07/18) | 50 (03/06) | 33 (01/03) | 33 (02/06) | 100 (02/02)f | 25 (01/04) |
IL-4+ | 78 (07/09) | 17 (01/06)a | 100 (01/01) | 75 (03/04) | 0 (00/03)d | 33 (01/03) |
IL-10+ | 31 (05/16) | 30 (03/10) | 25 (01/04) | 29 (02/07) | 50 (03/06) | 0 (00/04)e |