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Table 3 Cox regression analyses for factors predicting the progression of COVID-19

From: Increased circulating level of interleukin-6 and CD8+ T cell exhaustion are associated with progression of COVID-19

Covariate

HR (95% CI)

P

Age, years

1.038 (1.002–1.075)

0.039

Hypertension

2.295 (0.765–6.881)

0.138

Fever

1.278 (0.161–10.146)

0.816

Cough

3.336 (0.734–15.160)

0.119

C-reactive protein, mg/L

1.018 (1.005–1.030)

0.004

Procalcitonin, ng/ml

1.356 (1.092–1.684)

0.006

T lymphocyte count, /μl

0.999 (0.997–1.000)

0.119

CD4+ lymphocyte count, /μl

0.998 (0.995–1.001)

0.148

CD8+ lymphocyte count, /μl

0.998 (0.994–1.001)

0.192

B lymphocyte count, /μl

0.993 (0.984–1.002)

0.133

NK lymphocyte count, /μl

0.996 (0.989–1.002)

0.205

IL-6, pg/ml

1.021 (1.004–1.039)

0.014

Lactate, mmol/L

1.023 (1.004–1.043)

0.018

NLR

0.995 (0.904–1.095)

0.921

CD4+/total T lymphocyte

1.089 (0.041–29.038)

0.959

CD8+/total T lymphocyte

1.121 (0.019–67.083)

0.956

  1. Bold indicates the difference is statistically significant
  2. COVID-19 coronavirus disease 2019, IL-6 interleukin-6, NLR neutrophils/lymphocytes ratio, HR hazard ratio, CI confidence interval