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Table 2 Characteristics of severe patients with COVID-19 or H7N9

From: Comparison of patients hospitalized with COVID-19, H7N9 and H1N1

Variable

COVID-19

(n = 29)

H7N9

(n = 30)

P value

Characteristic

   

Age, years, median (range)

59 (32–80)

56 (21–82)

0.98

Male

15 (51.7%)

20 (66.7%)

0.29

Chronic heart disease

12 (41.4%)

4 (13.3%)

0.02

Chronic lung disease

2 (6.9%)

1 (3.3%)

0.61

Chronic renal disease

2 (6.9%)

1 (3.3%)

0.61

Chronic liver disease

0

3(10.0%)

0.24

Diabetes

5 (17.2%)

9 (30.0%)

0.36

Hypertension

9 (31.0%)

14 (46.7%)

0.29

Malignancy

0

0

1.00

Smoking history

1 (3.4%)

5 (16.7%)

0.19

Hospital stays

21.3 (6.9)

20.6 (8.9)

0.71

Dead

1 (3.4%)

5 (16.7%)

0.19

The days from illness onset to severity

8.0 (4.6)

5.2 (2.1)

 < 0.01

Symptoms

   

Fever (≥ 37.3 ℃)

26 (89.7%)

27 (90.0%)

1.00

Any cough

15 (51.7%)

28 (93.3%)

 < 0.01

Dry cough

10 (34.5%)

10 (33.3%)

1.00

Yellow sputum

5 (17.2%)

18 (60.0%)

 < 0.01

Hemoptysis

1 (3.4%)

8 (26.7%)

0.03

Myalgia

5 (17.2%)

11 (36.7%)

0.14

Fatigue

8 (27.6%)

12 (40.0%)

0.41

Gastrointestinal symptoms

4 (13.8%)

7 (23.3%)

0.51

Laboratory findings and CT images

   

AST

27.5 (11.1)

111.1 (118.4)

 < 0.01

ALT

26.2 (17.4)

61.7 (54.0)

 < 0.01

CK

167.5 (31.0)

1272.3 (268.8)

 < 0.01

LDH

215.6 (50.6)

745.8 (512.9)

 < 0.01

Leukopenia

7 (24.1%)

7 (23.3%)

1.00

Lymphopenia

15 (51.7%)

27 (90.0%)

 < 0.01

Neutropenia

9 (31.0%)

2 (6.7%)

0.02

Neutrophilia

1 (3.4%)

28 (93.3%)

 < 0.01

Thrombocytopenia

4 (13.8%)

10 (33.3%)

0.12

Elevated CRP

19 (65.5%)

29 (96.7%)

 < 0.01

Duration of viral shedding

10.6 (6.6)

10.2 (6.4)

0.86

Lung lobes involvement

4

5

0.14

  1. Data are presented as mean (SD), medians (interquartile ranges) or No. (%)
  2. ALT alanine aminotransferase, AST aspartate transaminase, CK creatine kinase, LDH lactate dehydrogenas, CRP C-reactive protein