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Fig. 1 | Infectious Diseases of Poverty

Fig. 1

From: A new candidate vaccine for human brucellosis based on influenza viral vectors: a preliminary investigation for the development of an immunization schedule in a guinea pig model

Fig. 1

Schematic representation of the recombinant influenza viral vector construction destined to generate a vaccine against brucellosis. a Full size NS1 protein virulence factor for antagonizing interferon system and b deletion part of NS1 replaced by Brucella immunodominant proteins NS1-Omp 16, NS1-Omp 19, NS1-L7/L12 and NS1-Cu–Zn SOD. The blue box and red box b represent RNA binding site of NS1 and part of NS1 protein at amino acid position 80 for insertion brucellosis segment, respectively. PB2, PB1 and PA: Influenza A virus RNA polymerase subunits; HA: Hemagglutinin; NP: Nucleoprotein; NA: Neuraminidase; M: Matrix; NS1: Non–structural protein 1; NEP: Nuclear export protein. The scheme is not drawn according to scale

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Infectious Diseases of Poverty

ISSN: 2049-9957

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